Abstract:Carbon-carbon bond-forming hydroaminoalkylation reactions between trimethylamine and alkynes, alkenes, allenes, or a methylenecyclopropane (MCP) are achieved in the presence of titanium catalysts. The reactions take place by C−H bond activation at the methyl group of trimethylamine and therefore offer flexible and direct methods for the C−H functionalization of trimethylamine. The importance of the developed procedures for the synthesis of pharmaceutically relevant dimethylaminomethyl-substituted products is u… Show more
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