Catalytic autoantibodies in multiple sclerosis: Pathogenetic and clinical aspects

Abstract

The significance of catalytic autoantibodies abzymes in the pathogenesis of multiple sclerosis was evaluated in patients with different disease patterns and severity of disability.

Catalytic Activity of Certain Antibodies as a Potential Tool for Drug Synthesis and for Directed Prodrug Therapies

“…Administration of catalytic antibodies which possess VIPase activity to animal models cause hyperreactivity of an airway smooth muscle [17]. Other catalytic autoantibodies possesing protease activity were found in pathophysiology of certain autoimmune disorders, like Hashimoto's thyroiditis [18][19][20], multiple sclerosis (MS) [21][22][23], hemophilia A [24][25][26] and multiple myeloma [27]. The Bence-Jones proteins with peptidase activities, were found in urine of patients with multiple myeloma, *Address correspondence to this author at the Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, 9, 30-688 Kraków, Poland; E-mail: mfkonono@cyf-kr.edu.pl they are composed of light chains of human autoantibodies [28,29].…”