Catalytic asymmetric α-C(sp3)–H functionalization of amines

An Ugi Reaction Incorporating a Redox-Neutral Amine C–H Functionalization Step

“…4,5 Here we report a new type of Ugi-variant that enables the α-amidation of cyclic amines via redox-neutral α-C–H bond functionalization (eq 5). 6,7 …”

Construction of N‐Heterocycles through Cyclization of Tertiary Amines

“…As depicted in Figure , a diverse array of hydride acceptors, such as electron‐deficient olefins, alkynes, imines, carbonyl groups, nitrones, and cyclopropanes, has been developed to deliver different N‐heterocyclic compounds . Recently, cascade reactions involving multiple hydride transfer processes have been realized for the synthesis of polycyclic N‐heterocycles.…”

“…Recently, cascade reactions involving multiple hydride transfer processes have been realized for the synthesis of polycyclic N‐heterocycles. As the research topic regarding hydride‐transfer‐triggered cyclizations has been covered by several reviews, this Minireview only introduces some typical examples to elucidate the different approaches and highlights some recent significant progresses.…”

“…As depicted in Figure 3, ad iverse array of hydride acceptors, such as electron-deficient olefins,a lkynes,i mines, carbonyl groups,n itrones,a nd cyclopropanes, has been developed to deliver different N-heterocyclic compounds. [38][39][40][41][42] Recently,c ascade reactions involvingm ultiple hydride transfer processes have been realized for the synthesis of polycyclic N-heterocycles. As the research topic regarding hydride-transfer-triggered cyclizationsh as been covered by several reviews, [38][39][40][41][42] this Minireview only introduces some typical examples to elucidate the differenta pproaches and highlightss omer ecent significant progresses.…”

Synthesis of fused 3-cyano- and 3-carbamoyl-1,2,3,4-tetrahydroquinolines

“…10,11 Scheme 1 X = C(EWG) 2 ; EWG stands for electron withdrawing group There are only several examples which use this ap proach for cyclization of conjugated dialkylamines con taining only one accepting group at the double bond. 12 All of them require assistance of catalysts (HCl, HBr, trifluo roacetic or (-) camphorsulfonic acid). 13, 14 An alternative approach to the synthesis of fused het erocycles with one electron withdrawing group consists in the cyclization of a vinyl derivative containing two ac cepting groups and elimination one of them.…”