Catalytic Asymmetric Synthesis of Inherently Chiral Saddle‐Shaped Dibenzo[b,f][1,5]diazocines†
Jinmiao Zhou,
Mengyao Tang,
Xiaoyu Yang
Abstract:Comprehensive SummaryDibenzo[b,f][1,5]diazocines are a class of eight‐membered heterocycles, which exhibit unique rigid saddle‐shaped structure and possess inherent chirality. In this study, we report a convenient and straightforward method for the catalytic enantioselective synthesis of these unique chiral molecules through chiral phosphoric acid‐catalyzed dimerization of 2‐acylbenzoisocyanates. Notably, the addition of corresponding 2‐acylaniline as the co‐catalyst significantly improved the efficiency of th… Show more
Pd-catalyzed Suzuki–Miyaura coupling of tetramer 1 forms inherently chiral nor-heteracalixarenes 2 in high yields and ees. The chirality arises solely from the hindered through-the-annulus rotation of the low rim alkoxy substituent in ring A.
Pd-catalyzed Suzuki–Miyaura coupling of tetramer 1 forms inherently chiral nor-heteracalixarenes 2 in high yields and ees. The chirality arises solely from the hindered through-the-annulus rotation of the low rim alkoxy substituent in ring A.
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