“…Asymmetric reactions between imino glycine derivatives and α,β-unsaturated aldehydes were first developed by Belokon et al, wherein a chiral glycinate Schiff base Ni(II) complex reacted with substituted acroleins under basic conditions to yield Michael addition products in excellent chiral induction (Scheme A). , An organocatalyzed asymmetric version of this transformation with nonchiral Ni(II) complexes afforded Michael adducts in up to 95% ee (Scheme B) . Other than the nickel complexes, free glycine ester Schiff bases are also good partners for Michael additions under chiral PTC conditions, and an optically pure bicyclic amino acid, which is the key intermediate for Telaprevir production, was prepared in up to 93% ee (Scheme C). − Asymmetric 1,3-dipolar cycloaddition of imino glycinates with methacrolein was discovered by Carretero et al, and chiral pyrrolidines were prepared in good enantioselectivity (69% ee) (Scheme D). , …”