Catalytic asymmetric borane reduction of prochiral ketones using chiral camphor‐derived mercapto‐alcohols

Abstract

CommunicationCatalytic asymmetric borane reduction of prochiral ketones using chiral camphor-derived mercapto-alcohols ZHOU, Yong-Gui(FgJ;rkB) HOU, Xue-Long(#%%)' DAI, Li-Xin (a3m) Abstract Easily available D-(+)-camphor-derived chiral mercapt*alcohols 2 and 3 were employed for catalytic asymmetric borane reduction of aromatic ketones. Moderate enantioselectivities with e.e. 20.2-72.1% were obtained with 10 mol% catalyst. Opposite asymmetric induction was achieved' when mercaptc-alcohols 2 and 3 were used.