Catalytic application of selenium and tellurium compounds as glutathione peroxidase enzyme mimetics

Abstract

A glutationa peroxidase (GPx) é uma importante enzima que faz parte do sistema de defesa do organismo frente a substâncias nocivas formadas durante o metabolismo do oxigênio, como peróxidos e seus derivados. Diversas estratégias para desenvolver novos miméticos, assim como para aumentar a atividade mimética da GPx em compostos como disselenetos, selenetos e teluretos, vêm sendo propostas nos últimos anos. Nesta revisão é apresentado um balanço, dos últimos dez anos, referente ao desenvolvimento e à avaliação de catalisadores organoselênio ou organotelúrio capazes de mimetizar a atividade da GPx. Diferentes mecanismos de ação destes compostos também são apresentados, de acordo com os novos avanços desta relevante área de pesquisa.This review covers the past decade of intensive research on the design, synthesis and screening of organoselenides and tellurides as catalyst able to mimic the activity of the selenoenzyme glutathione peroxidase (GPx). This important enzyme forms part of the detoxification system in humans which deals with harmful peroxides and their byproducts formed during oxygen metabolism. Several strategies to enhance the GPx-like activity of compounds such as diselenides, selenides and tellurides have been proposed in recent years. Different mechanisms of action of these compounds are also presented in this review highlighting new advances in this exciting research field.

Oxidative Stress and Novel Antioxidant Approaches to Reduce Diabetic Complications

“…Several laboratories have reported the synthesis and characterisation of novel small selenium compounds as functional mimics of GPx, either by modifying the basic structure of ebselen or by incorporating some structural features of the native enzyme (Alberto et al 2010;Back 2009;Bhabak & Mugesh 2010). These synthetic mimics can be classified into three major categories: (i) cyclic selenenyl amides having a Se-N bond, (ii) diaryl diselenides, and (iii) aromatic or aliphatic monoselenides (Bhabak & Mugesh 2010).…”

Synthesis, Characterization andin vitroAntioxidant Activity of New ChiralN-boc Organotellurium Compounds, (CH3)3OC(O)NHCH(R)C(O)NHCH2-CH2Te-C6H4-4-OCH3, Containing Carbamate and Peptide Groups

“…Numerous organochalcogen compounds containing amine, peptide/amide and carbamate groups enhances the rates of their redox reactions 16,22,23,47 and the effect of these groups on the activity of organotellurium compounds was expected to be more pronounced than that of corresponding organoselenium compounds. 47,23 The biological activity of chiral organochalcogen compounds may be specific.…”

“…47,23 The biological activity of chiral organochalcogen compounds may be specific. Recently reported that the organoselenium and tellurium compounds which contain the secondary interactions between chalcogen atom and other heteroatoms [TeX, X = N, O, S, Cl, Br, I] through internal chelation play an important role in the catalytic antioxidant activity.…”

“…Recently reported that the organoselenium and tellurium compounds which contain the secondary interactions between chalcogen atom and other heteroatoms [TeX, X = N, O, S, Cl, Br, I] through internal chelation play an important role in the catalytic antioxidant activity. [48][49][50] There are numerous synthetic and natural chiral organoselenium compounds [20][21][22][23][24][25][26][43][44][45][46] but there has not been studied antioxidant properties of chiral organotellurium compounds containing peptide and carbamate functionalities.…”

Microwave-assisted one-pot synthesis of symmetrical diselenides, ditellurides and disulfides from organoyl iodides and elemental chalcogen catalyzed by CuO nanoparticles

“…Several types of these compounds play a crucial role in biology and biochemistry. For instance, they have been used as antioxidants and apoptosis inducers, and their role in the degradation of hydroperoxides and in the chemoprevention of cancer in a variety of organs has been exploited [7,8].…”