Catalytic antibodies: prospects for the use in organic synthesis

Kochetkov, N. K.

doi:10.1070/rc1998v067n12abeh000439

Cited by 4 publications

(1 citation statement)

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“…The libraries of antibodies generated as the result of antigenic challenges to the immune system invariably contain high affinity binders or receptors. This feature of the immune response was also exploited to evolve antibodies against transition state analogues, thus generating antibodies endowed with catalytic activity (TANAKA, 2002;KOCHETKOV, 1998). Another way to exploit the biology of living organisms to generate combinatorial libraries is the biological display technology, which allows the preparation of random peptides fused to proteins normally expressed on the surface of microorganisms.…”

Section: Biological Librariesmentioning

confidence: 99%

The Effects of Combinatorial Chemistry and Technologies on Drug Discovery and Biotechnology – a Mini Review

Seneci¹,

Fassina²,

Frecer³

et al. 2014

Nova Biotechnologica Et Chimica

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The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial chemistry/high throughput synthesis in medicinal chemistry; the rational design of combinatorial libraries using computer-assisted combinatorial drug design; and the use of combinatorial technologies in biotechnology. The impact of “combinatorial thinking” in drug discovery in general, and in the examples reported in details, is critically discussed. Finally, an expert opinion on current and future trends in combinatorial chemistry and combinatorial technologies is provided.

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Section: Biological Librariesmentioning

confidence: 99%