Catalytic and SERS Activities of Tryptophan‐EDTA Capped Silver Nanoparticles

Mondal, Sudipta; Verma, Sandeep

doi:10.1002/zaac.201400056

Cited by 7 publications

(5 citation statements)

References 77 publications

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“…Another plausible explanation for the decreased accuracy in SERS is the use of EDTA during plasma collection. EDTA is a molecule for complexing metal ions and it has been found that its carboxylate groups can bind to nanoparticles surface and be responsible for the generation of new spectral bands [37]. This could potentially obscure the detection of the biological information in the derived spectra.…”

Section: Discussionmentioning

confidence: 99%

Raman spectroscopic techniques to detect ovarian cancer biomarkers in blood plasma

Paraskevaidi

Ashton

Stringfellow

et al. 2018

Talanta

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Robust diagnosis of ovarian cancer is crucial to improve patient outcomes. The lack of a single and accurate diagnostic approach necessitates the advent of novel methods in the field. In the present study, two spectroscopic techniques, Raman and surface-enhanced Raman spectroscopy (SERS) using silver nanoparticles, have been employed to identify signatures linked to cancer in blood. Blood plasma samples were collected from 27 patients with ovarian cancer and 28 with benign gynecological conditions, the majority of which had a prolapse. Early ovarian cancer cases were also included in the cohort (n = 17). The derived information was processed to account for differences between cancerous and healthy individuals and a support vector machine (SVM) algorithm was applied for classification. A subgroup analysis using CA-125 levels was also conducted to rule out that the observed segregation was due to CA-125 differences between patients and controls. Both techniques provided satisfactory diagnostic accuracy for the detection of ovarian cancer, with spontaneous Raman achieving 94% sensitivity and 96% specificity and SERS 87% sensitivity and 89% specificity. For early ovarian cancer, Raman achieved sensitivity and specificity of 93% and 97%, respectively, while SERS had 80% sensitivity and 94% specificity. Five spectral biomarkers were detected by both techniques and could be utilised as a panel of markers indicating carcinogenesis. CA-125 levels did not seem to undermine the high classification accuracies. This minimally invasive test may provide an alternative diagnostic and screening tool for ovarian cancer that is superior to other established blood-based biomarkers.

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Section: Discussionmentioning

confidence: 99%

Raman spectroscopic techniques to detect ovarian cancer biomarkers in blood plasma

Paraskevaidi

Ashton

Stringfellow

et al. 2018

Talanta

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“…33 EDTA-capped AgNPs yielded absorptions at 1061 cm À1 , 1401 cm À1 , 1632 cm À1 and 3446 cm À1 , which were assigned to C-O single-bond vibrations, asymmetric carboxylate group stretching, amide-I C]O stretching, and O-H stretching vibrations, respectively. 34 This IR spectrum strongly conrmed the capping of the AgNPs through direct bonding of EDTA.…”

Section: Ftir Studiesmentioning

confidence: 98%

Role of capping agents in controlling silver nanoparticles size, antibacterial activity and potential application as optical hydrogen peroxide sensor

et al. 2016

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“…EDTA was chosen as a capping agent because of its good anionic interaction with metal sulfides and control of morphology. [23][24][25] The effect of precursor material concentration (i.e. Ni-(NO 3 ) 2 •6H 2 O, CH 4 N 2 S, and EDTA) on the formation mechanism of nickel sulfide hierarchical structures and phase control was investigated.…”

Section: Introductionmentioning

confidence: 99%

Shape controlled synthesis of hierarchical nickel sulfide by the hydrothermal method

et al. 2014

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Hierarchical structures of nickel sulfide have been grown by the hydrothermal method. Nickel nitrate hexahydrate and thiourea were used as precursor materials to synthesize nickel sulfide. Ethylenediaminetetraacetic acid was used as a capping agent to achieve monodispersity. The different phases of nickel sulfide and its dependency on the precursor concentration were analyzed by X-ray diffractometry. Transmission electron microscopy analysis was used to confirm the phase changes and morphological behavior of the synthesized material. The morphological evolution of the hierarchical structure formation was studied systematically by scanning electron microscopy. In this study, we explore a novel method to control the synthesis of nickel sulfide hierarchical structures by varying the precursor concentration. The two mixed phases enhanced the catalytic activity in the 4-nitro phenol reduction reaction.

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Catalytic and SERS Activities of Tryptophan‐EDTA Capped Silver Nanoparticles

Cited by 7 publications

References 77 publications

Raman spectroscopic techniques to detect ovarian cancer biomarkers in blood plasma

Raman spectroscopic techniques to detect ovarian cancer biomarkers in blood plasma

Role of capping agents in controlling silver nanoparticles size, antibacterial activity and potential application as optical hydrogen peroxide sensor

Shape controlled synthesis of hierarchical nickel sulfide by the hydrothermal method

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