Catalytic Activity of Selected Serum Enzymes in Experimental Sarcocystosis in Calves

Nevole, M; Malota, L.; Koudela, Břetislav

doi:10.2754/avb198655010081

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Activities of blood serum LDH were investigated in seven calves during the course of experimental sarcocystosis [35]. Development of muscular cysts was accompanied by degenerative changes and rupture of muscle fibers and sometimes even myositis develops.…”

Section: Ldh In Liver and Muscle Diseasesmentioning

confidence: 99%

Clinical and Diagnostic Significance of Lactate Dehydrogenase and Its Isoenzymes in Animals

Klein

Nagy

Tóthová

et al. 2020

Veterinary Medicine International

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Lactate dehydrogenase (LDH) is widely distributed enzyme in cells of various living systems where it is involved in carbohydrate metabolism catalyzing interconversion of lactate and pyruvate with NAD+/NADH coenzyme system. Cells of tissues are direct source of lactate dehydrogenase isoenzymes that are naturally distributed in blood plasma/serum of animals and humans producing characteristic profile. This profile depends on intracellular isoenzyme concentration in all tissues that contribute to the common pool of lactate dehydrogenases in plasma/serum as a consequence of natural cell degradation. LDH is widely distributed in the body, high activities are found in the heart, liver, skeletal muscle, kidney, and erytrocytes, whereas lesser amounts are found in the lung, smooth muscle, and brain. Because of its widespread activities in numerous body tissues, LDH is elevated in a variety of disorders. There are many conditions that contribute to increased activity of LDH. An elevated total LDH value is a rather nonspecific finding. Therefore, LDH assays assume a more clinical significance when separated into isoenzyme fractions. The activity of LDH and its serum and tissue patterns and composition show great variations between the species. These differences do not allow using catalytic activities of LDH isoenzymes from one species to another. Instead, the pattern of serum LDH isoenzymes should be interpreted in respect to its species origin that is important in particular in veterinary medicine. Determination of total LDH activity and its isoenzyme pattern in serum of mammals had become one of the biochemical indicators in the assessment of organ disorders. When the content of cells is released from tissue to plasma, as on cell injury, the LDH isoenzyme pattern of the serum changes in favour of the profile of the affected organ (tissue) that can be used in the diagnostic practice.

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Section: Ldh In Liver and Muscle Diseasesmentioning

confidence: 99%

Clinical and Diagnostic Significance of Lactate Dehydrogenase and Its Isoenzymes in Animals

Klein

Nagy

Tóthová

et al. 2020

Veterinary Medicine International

View full text Add to dashboard Cite

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“…Haematological data for cattle with sarcocystosis are limited. Blood enzyme activity such as creatinine kinase (CK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), γ-glutamyl transferase (GGT) and sorbitol dehydrogenase (SDH) were studied in experimental cases of sarcocystosis in cattle approximately three decades ago (Fayer and Johnson 1975;Jungmann et al 1977;Prasse and Fayer 1981;Dessouky et al 1984;Nevole et al 1986). In the past decade scientific data about the activity of blood enzymes in experimental sarcocystosis cases in pigs have been presented (Reiner et al 2002;Hepp 2006;Reiner et al 2009; Hübner-Weitz 2010).…”

mentioning

confidence: 99%

Biochemical profile of blood in naturally occurring Sarcocystis infection in cattle

et al. 2018

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The aim of this study was to determine the biochemical blood indicators in Lithuanian Black-and-White cattle with regard to the intensity of their infection with Sarcocystis spp. In total 945 bull muscle samples and 120 blood samples were used for the analysis. Aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) were increased in infected animals relative to uninfected animals. The AST levels differed significantly between the no infection, low, and moderate infection groups (P < 0.05); ALP differed between the no infection and moderate infection groups (P < 0.05); and ALT differed between the no infection, low infection and intense infection groups (P < 0.05). Total protein levels were higher than physiological limits and differed significantly between the no infection, low infection and intense infection groups (P < 0.05). Iron levels were at the lowest physiological limits and differed significantly between the no infection and low infection groups, as well as between the low infection and intense infection groups (P < 0.05). Triglyceride levels were at their physiological limits, and differed significantly between all examined groups (P < 0.05). The results show that changes in the biochemical markers ALP, AST and ALT are related to the intensity of the Sarcocystis spp. infection.

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Catalytic Activity of Selected Serum Enzymes in Experimental Sarcocystosis in Calves

Cited by 2 publications

References 3 publications

Clinical and Diagnostic Significance of Lactate Dehydrogenase and Its Isoenzymes in Animals

Clinical and Diagnostic Significance of Lactate Dehydrogenase and Its Isoenzymes in Animals

Biochemical profile of blood in naturally occurring Sarcocystis infection in cattle

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