Catalyst-free one-pot synthesis and antioxidant evaluation of highly functionalized novel 1,4-dihydropyridine derivatives

Highly Efficient Electrocarboxylation Method to Synthesize Novel Acid Derivatives of 1,4-Dihydropyridines and to Study Their Antimicrobial Activity

“…Extensive pharmaceutical research furnished an extended catalog of medicines containing 1,4-DHP as the nucleus, and it is evident by the existence in many commercially available drugs such as amlodipine 1 (hypertension), nifedipine 2 (treats high blood pressure), isradipine 3 (calcium channel blocker), nimodipine 4 (decreases brain damage), among other drugs. Pharmaceutical potencies of 1,4-dihydropyridines have also been studied in other significant areas like anticancer, 5 antimutagenic, 6 neuroprotective, 7 growth stimulants, 8 antioxidant, 9 and radioprotective agents. 10 Biological potencies of 1,4-DHP skeleton have been greatly enhanced by the structural modifications and these modifications influence the structure−activity relationship.…”

Improved One-Pot, Four-Component Strategy to Access ­Functionalized Dihydropyridines by Using 4-(N,N-Dimethylamino)pyridine as a Catalyst

“…[12][13][14][15] 4-(N,N-Dimethylamino)pyridine (DMAP) can promote a number of organic transformations as a reusable catalyst, [16][17][18] and the combination of an MCR approach with organocatalysis has proved to be a most effective strategy. 19 In a continuation of our current work devoted to the synthesis of medicinally important heterocycles by using green solvents or catalysts, [20][21][22][23][24][25][26][27][28][29][30] R. Ramesh et al…”