Catalepsy and Comparing Gamma-Hydroxybutyrate, 1,4-Butanediol, and Gamma-Butyrolactone

Phattanarudee, Siripan; Maher, Timothy J.; Towiwat, Pasarapa

doi:10.1016/b978-0-12-800212-4.00045-5

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Many antipsychotic drugs are known to have extrapyramidal side-effects. Therefore it is important to determine whether a drug being screened for antipsychotic property has this side effect using catalepsy test [25]. In this study, the results of catalepsy tests showed that BPE and NLE at 600 mg/kg b.w caused catalepsy and potentiated haloperidol-induced catalepsy in mice, suggesting that Newbouldia laevis extracts might have extrapyramidal effects at high doses.…”

Section: Discussionmentioning

confidence: 93%

Crude and Partition Extracts of Newbouldia laevis Leaves Attenuate Excitotoxin-induced Stereotypy in Mice

Kolawole

Adeyeba

Awodele

et al. 2020

EJMP

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Aims: This study was designed to investigate the effects of crude ethanol and partition extracts of Newbouldia laevis leaves on excitotoxin-induced stereotypy in mice. Place and Duration of Study: The study was carried out in the Laboratory of the Department of Pharmacology and Therapeutics, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria, between July and October, 2020. Methodology: Following pretreatment of mice with graded doses (150 - 600 mg/kg b.w) of crude extract (NLE) and partition fractions [n-butanol partition fraction (BPE), n-hexane partition fraction (HPE) and ethylacetate partition fraction (EAPE)] of Newbouldia laevis leaves, stereotypy was induced by the administration of methamphetamine (35 mg/kg b.w) and apomorphine (5mg/kg b.w.), and stereotypy scores were recorded thereafter. The effects of BPE and NLE on catalepsy were also determined. Statistical significance was taken at P<0.05 Results: In both apomorphine and methamphetamine models, stereotyped behavior was significantly decreased (P<0.05) in the treated mice compared to the control. The degree of protection offered by Newbouldia laevis extracts against excitotoxin-induced stereotypy was in the order: BPE>NLE>EAPE>HPE. In the catalepsy test, BPE (600 mg/kg b.w) significantly potentiated haloperidol-induced catalepsy compared to control (P<0.05). Likewise, NLE significantly increased catalepsy compared to control (P<0.05). Conclusion: Findings from this study indicate that crude and partition extracts of Newbouldia laevis leaves attenuated stereotypy in methamphetamine and apomorphine models, and thus could be effective remedy for schizophrenia-like psychosis.

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Section: Discussionmentioning

confidence: 93%

Crude and Partition Extracts of Newbouldia laevis Leaves Attenuate Excitotoxin-induced Stereotypy in Mice

Kolawole

Adeyeba

Awodele

et al. 2020

EJMP

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“…Cataleptogenic action (catalepsy), i.e., the ability of an animal to hold an artificially given posture, is one of the manifestations of undesirable side effects of extrapyramidal drugs with neuroleptic activity [ 47 ]. Nanoparticles with haloperidol were tested in 8 animals.…”

Section: Methodsmentioning

confidence: 99%

Hybrid Nanoparticles for Haloperidol Encapsulation: Quid Est Optimum?

et al. 2021

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The choice of drug delivery carrier is of paramount importance for the fate of a drug in a human body. In this study, we have prepared the hybrid nanoparticles composed of FDA-approved Eudragit L100-55 copolymer and polymeric surfactant Brij98 to load haloperidol—an antipsychotic hydrophobic drug used to treat schizophrenia and many other disorders. This platform shows good drug-loading efficiency and stability in comparison to the widely applied platforms of mesoporous silica (MSN) and a metal–organic framework (MOF). ZIF8, a biocompatible MOF, failed to encapsulate haloperidol, whereas MSN only showed limited encapsulation ability. Isothermal titration calorimetry showed that haloperidol has low binding with the surface of ZIF8 and MSN in comparison to Eudragit L100-55/Brij98, thus elucidating the striking difference in haloperidol loading. With further optimization, the haloperidol loading efficiency could reach up to 40% in the hybrid Eudragit L100-55/Brij98 nanoparticles with high stability over several months. Differential scanning calorimetry studies indicate that the encapsulated haloperidol stays in an amorphous state inside the Eudragit L100-55/Brij98 nanoparticles. Using a catalepsy and open field animal tests, we proved the prolongation of haloperidol release in vivo, resulting in later onset of action compared to the free drug.

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Catalepsy and Comparing Gamma-Hydroxybutyrate, 1,4-Butanediol, and Gamma-Butyrolactone

Cited by 2 publications

References 36 publications

Crude and Partition Extracts of Newbouldia laevis Leaves Attenuate Excitotoxin-induced Stereotypy in Mice

Crude and Partition Extracts of Newbouldia laevis Leaves Attenuate Excitotoxin-induced Stereotypy in Mice

Hybrid Nanoparticles for Haloperidol Encapsulation: Quid Est Optimum?

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