2003
DOI: 10.1016/s1096-7176(03)00026-0
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Catalase and chondroitin sulfate derivatives against thrombotic effect induced by reactive oxygen species in a rat artery

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Cited by 18 publications
(22 citation statements)
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“…This view is confirmed by the data of adenovirus-mediated extracellular SOD gene therapy in respect to the decrease of the neointima formation in balloon-denuded rabbit aorta [55]. Moreover, the effect of gene therapy was pronounced only after local (via catheter), but not systemic (intraaortally without catheter) gene delivery [55], whereas the modified antioxidant enzymes were active therapeutically into rat artery after systemic (intravenous bolus) administration [13,14]. On the other hand, destruction of the glycocalyx by active oxygen metabolites promotes cellular injury [56,57].…”
Section: Antithrombotic Activity Of Sod and Chs Derivativesmentioning
confidence: 60%
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“…This view is confirmed by the data of adenovirus-mediated extracellular SOD gene therapy in respect to the decrease of the neointima formation in balloon-denuded rabbit aorta [55]. Moreover, the effect of gene therapy was pronounced only after local (via catheter), but not systemic (intraaortally without catheter) gene delivery [55], whereas the modified antioxidant enzymes were active therapeutically into rat artery after systemic (intravenous bolus) administration [13,14]. On the other hand, destruction of the glycocalyx by active oxygen metabolites promotes cellular injury [56,57].…”
Section: Antithrombotic Activity Of Sod and Chs Derivativesmentioning
confidence: 60%
“…(2C), and, respectively, between native CAT and the control (not shown), on the other hand. The antithrombotic effects of CAT-CHS and CAT+CHS are similar and significantly exceed the effect of native CAT and free CHS [13]. In a rat model of arterial injury, the effect of CAT is associated with inhibition of platelet aggregation.…”
Section: Antithrombotic Activities Of Cat and Chs Derivativesmentioning
confidence: 92%
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