Catalase activity, lipid peroxidation, cholesterol and triglyceride levels in alloxan – induced diabetes mellitus in female and male rats.

Ebuehi, Osaretin Albert Taiwo; Ajuluchukwu, A. E.; Afolabi, Olayinka; Ebuehi, O M; Akinwande, A. I.

doi:10.4314/nqjhm.v19i1.50202

Cited by 17 publications

(19 citation statements)

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“…The plasma and tissue (liver and kidney) lipid peroxidation (measured by MDA) increased in diabetic rats treated with insulin, which is consistent with previous reports Ebuehi et al (2009) and studies in humans (Clapés et al, 2001). However, lipid peroxidation in the diabetic groups treated with WAQE was similar to that found in healthy normal animals.…”

Section: Discussionsupporting

confidence: 81%

Antioxidant and Hypoglycemic Effects of Watercress (Nasturtium Officinale) Extracts in Diabetic Rats

Fenton-Navarro¹,

Martínez²,

Castro³

et al. 2018

Afr J Tradit Complement Altern Med

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Background: Watercress is a semi-aquatic plant used in traditional medicine to treat various ailments, such as flu, cough, avitaminosis, and anorexia; it is also used as a diuretic and for hypoglycemia treatment in diabetes. In this study, we report the antioxidant and hypoglycemic activity of orally administered aqueous (WAQE), acetonic (WAE), and alcoholic (WOHE) watercress extracts. The effect of subchronic administration of watercress extracts on oxidative stress was also studied. Materials and Methods: WAQE, WAE, and WOHE were obtained and administered orally. Alloxan (200 mg/kg) and streptozotocin (60 mg/kg) were applied to induce hyperglycemia in male Wistar rats. Phenolic and flavonoid content, as well as antioxidant activity of the extracts were measured. The acute and subchronic effects (8 weeks) of WAQE were evaluated. The activity of antioxidant enzymes levels of malondialdehyde, hepatic enzyme markers in the serum, and renal function markers, were assessed. Histopathological evaluation of the pancreas, kidney, and liver was performed using hematoxylin-eosin staining. Results: Watercress extracts have high concentrations of phenols, polyphenols, and flavonoids, in addition to a very high antioxidant effect. The hypoglycemic effect of WAQE upon acute administration was 76.6% higher than that of insulin. When administered chronically, glucose levels were normalized on the third week up to the eighth week. Furthermore, the antioxidant enzymes and biochemical parameters improved. Conclusion: WAQE administration to diabetic rats reduced oxidative stress damage and decreased glucose levels. This study supports the use of this plant for the treatment of diabetes.

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Section: Discussionsupporting

confidence: 81%

Antioxidant and Hypoglycemic Effects of Watercress (Nasturtium Officinale) Extracts in Diabetic Rats

Fenton-Navarro¹,

Martínez²,

Castro³

et al. 2018

Afr J Tradit Complement Altern Med

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show abstract

“…Measurements of antioxidant enzymes activity and lipid peroxidation were done according to standard procedures: catalase 19,21 ; superoxide dismutase (SOD) 21 ; malondialdehyde (MDA) [21][22] ; reduced glutathione (GSH) and glutathione-S-transferase (GST) were determined using the methods of Beers and Seizer 19 and Beuge and Aust. …”

Section: Measurement Of Haematological Parameters Antioxidant Enzymementioning

confidence: 99%

Polycyclic Aromatic Hydrocarbon, Haematological and Oxidative Stress Levels in Commercial Photocopier Operators In Lagos, Nigeria

Awodele

Akindele

Adebowale

et al. 2015

Ghana Medical Journal

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“…Measurements of antioxidant enzyme activity and lipid peroxidation were performed according to standard procedures: catalase [27][28][29]; superoxide dismutase (SOD) [29]; malondialdehyde (MDA) [29,30]; reduced glutathione (GSH) and Glutathione-Stransferase (GST) were determined using the methods of Beers and Seizer [27] and Beuge and Aust [28].…”

Section: Measurement Of Haematological Parameters Antioxidant Enzymementioning

confidence: 99%

Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

Awodele

Olayemi

Nwite

et al. 2011

J Infect Dev Ctries

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Introduction: Among opportunistic pathogens associated with acquired immunodeficiency syndrome (AIDS), Mycobacterium tuberculosis is distinguished by its relative virulence and potential for person-to-person transmission. Oxidative stress is associated with TB infection with a high level in patients with HIV-TB co-infection. However, the comparative level of oxidative stress in HIV patients on highly active antiretroviral therapy (HAART) and naïve (untreated) HIV patients is not clear. Methodology: This study is aimed to determine the level of oxidative stress and haematological parameters in HIV patients (naïve), HIV patients undergoing HAART, and HIV-TB co-infected patients. In total, 100 consenting subjects were recruited from the AIDS Prevention Iniative in Nigeria (APIN) Clinic. For controls, normal male healthy volunteers were recruited from the blood donor clinic and females from the APIN clinic staff members, both of the Lagos University Teaching Hospital. Measurements of antioxidant enzyme activity and lipid peroxidation were performed according to standard procedures. Haematological parameters were determined using a fully automated hematology analyzer. Results: Red blood cells significantly decreased (P≤0.001) in all patients when compared with control subjects. The lipid peroxidation (MDA) was significantly high (P≤0.05) in naive patients when compared to HIV patients on HAART. The decrease in the levels of GSH in both naive and HIV-TB co-infected patients (P≤0.001) and HIV patients on HAART (P<0.05) were significant when compared to control patients. Conclusion: There is lower antioxidant level and higher MDA in naive and HIV-TB co-infected patients as compared to HIV patients on HAART and the seronegative patients.

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Catalase activity, lipid peroxidation, cholesterol and triglyceride levels in alloxan – induced diabetes mellitus in female and male rats.

Cited by 17 publications

References 0 publications

Antioxidant and Hypoglycemic Effects of Watercress (Nasturtium Officinale) Extracts in Diabetic Rats

Antioxidant and Hypoglycemic Effects of Watercress (Nasturtium Officinale) Extracts in Diabetic Rats

Polycyclic Aromatic Hydrocarbon, Haematological and Oxidative Stress Levels in Commercial Photocopier Operators In Lagos, Nigeria

Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

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