Cat-Scratch Disease Associated With a Vertebral Osteolytic Lesion

Shanon, Amir; Marchessault, J. H. V.; McDonald, Peter J.

doi:10.1097/00006454-198901000-00013

Cited by 23 publications

(9 citation statements)

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“…A number of other complications can occur in association with CSD, including ophthalmic manifestations (74); pneumonia and pleural effusion, which occur in 0.2% of patients (101,118); and musculoskeletal manifestations. Osteomyelitis is a rare manifestation, occurring in 0.3% of patients; it may affect any bone (2,34,36,46,172). Occasionally there is a direct extension from an adjacent involved lymph node.…”

Section: Complications Of Cat Scratch Diseasementioning

confidence: 99%

Bartonella spp. as emerging human pathogens

1997

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Members of the genus Bartonella (formerly Rochalimaea) were virtually unknown to modern-day clinicians and microbiologists until they were associated with opportunistic infections in AIDS patients about 6 years ago. Since that time, Bartonella species have been associated with cat scratch disease, bacillary angiomatosis, and a variety of other disease syndromes. Clinical presentation of infection with Bartonella ranges from a relatively mild lymphadenopathy with few other symptoms, seen in cat scratch disease, to life-threatening systemic disease in the immunocompromised patient. In some individuals, infection manifests as lesions that exhibit proliferation of endothelial cells and neovascularization, a pathogenic process unique to this genus of bacteria. As the spectrum of disease attributed to Bartonella is further defined, the need for reliable laboratory methods to diagnose infections caused by these unique organisms also increases. A brief summary of the clinical presentations associated with Bartonella infections is presented, and the current status of laboratory diagnosis and identification of these organisms is reviewed.

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Section: Complications Of Cat Scratch Diseasementioning

confidence: 99%

Bartonella spp. as emerging human pathogens

1997

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“…To our knowledge, reports of 23 cases of cat-scratch disease with bone involvement have been published [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Only 4 of the 23 cases occurred in adults [14,15,21,22].…”

Section: We Describe 2 Adult Patients (1 Of Whom Was Infected With Humentioning

confidence: 99%

Vertebral Osteomyelitis Due toBartonella henselaein Adults: A Report of 2 Cases

Verdon¹,

Geffray²,

Collet³

et al. 2002

CLIN INFECT DIS

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“…Of these, 88 manuscripts were reviewed and found to meet inclusion criteria. After exclusion, a total of 32 reports[ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ] were ultimately selected for full review [ Figure 1 ].…”

Section: Resultsmentioning

confidence: 99%

Atlantoaxial instability secondary to Bartonella henselae osteomyelitis managed surgically by atlantoaxial instrumentation: A case report and systematic review

Mathkour

Chu

Scullen

et al. 2022

J Craniovert Jun Spine

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Cat scratch disease (CSD), caused by Bartonella henselae , may atypically present with vertebral osteomyelitis. Antibiotic regimens are tailored to presentation, which is markedly variable and not well defined for any atypical disease. In cases of spinal instability, the use of antibiotics alone may not be sufficient. Atlantoaxial instability caused by osteomyelitis is a rare complication of CSD. In this report, we describe the rare case of vertebral osteomyelitis complicated by atlantoaxial instability, requiring both antibiotics and atlantoaxial fusion. We discuss our case, surgical technique, rationale, and outcome. In addition, we conducted a systematic review of the literature of vertebral osteomyelitis in pediatric secondary to B. henselae . A 2-year-old child presented with a 2-month history of irritability, fever, and rigid neck pain along with a recent history of feline exposure. Physical examination revealed cervical tenderness and decreased range of motion. Computed tomography (CT) showed osteolysis of the right C1 lateral mass and pars articularis; T1-weighted magnetic resonance imaging with contrast showed enhancement around the right C1 lateral mass. The titer for B. henselae was high. A diagnosis of cat scratch osteomyelitis with cervical instability was made, for which the patient underwent surgery with atlantoaxial fusion. Postoperative imaging demonstrated resolution of the contrast-enhanced lesion. At 6-year follow-up, the patient showed no signs of residual complications from surgical intervention with a solid fusion. Our review revealed 44 cases of pediatric CSD vertebral osteomyelitis. Conservative management with antibiotic employed in 86% while antibiotics with surgical intervention in 14% of the cases. Surgical intervention was most often in the form of incision for drainage and decompression without fusion. Average follow-up 10 months with 86% achieved complete resolution. Cervical instability caused by osteolysis is a rare complication of CSD. This can subsequently lead to vertebral instability, requiring definitive surgical intervention.

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Cat-Scratch Disease Associated With a Vertebral Osteolytic Lesion

Cited by 23 publications

References 0 publications

Bartonella spp. as emerging human pathogens

Bartonella spp. as emerging human pathogens

Vertebral Osteomyelitis Due toBartonella henselaein Adults: A Report of 2 Cases

Atlantoaxial instability secondary to Bartonella henselae osteomyelitis managed surgically by atlantoaxial instrumentation: A case report and systematic review

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