Cat scratch disease: analysis of 130 seropositive cases

Murakami, Kyoko; Tsukahara, Masato; Tsuneoka, Hidehiro; Iino, Hidechika; Ishida, Chizuru; Tsujino, Kumiko; Umeda, Akira; Furuya, Tomoko; Kawauchi, Shigeto; Sasaki, Kohsuke

doi:10.1007/s10156-002-0194-6

Cited by 98 publications

(68 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The isolation and establishment of Bartonella strains are extremely important for both etiological diagnosis and epidemiological and genetical analysis of the isolates. Though many clinical cases of CSD have been reported in Japan (20,24,33), there are to date no available reports of the isolation of B. henselae from human cases in Japan.B. henselae type II was detected in 18% of the isolates from CSD patients in the Netherlands (3), and 94% of cat isolates in Germany (27).…”

mentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

“…Most cases are diagnosed based on clinical manifestations, the history of contacts with cats, serology (14,20,24,26,28,33) or PCR-based methods for examining the biopsy specimens (2, 10, 28). However, the isolation of the organism from patients is relatively difficult and only a few cases of the organism isolation have been reported worldwide (7,9,18,25), because suitable material is not available, the culture conditions are not appropriate or the organism shows fastidious, cytozoic and slow-growth properties.…”

mentioning

confidence: 99%

See 2 more Smart Citations

First Isolation of Bartonella henselae Type I from a Cat‐Scratch Disease Patient in Japan and Its Molecular Analysis

Maruyama

Izumikawa

Miyashita

et al. 2004

Microbiology and Immunology

View full text Add to dashboard Cite

Cat-scratch disease (CSD) is a worldwide zoonosis primarily caused by Bartonella henselae (5,11,20,24,33,34), but Bartonella clarridgeiae has also been linked to a few human cases of CSD (17,19). The organism also causes bacillary angiomatosis (15,31) and peliosis (32) in immunocompromised individuals and bacteremia in immunocompetent individuals. The clinical manifestation of CSD is mainly characterized by pyrexia, papules on the site of the cat scratch or bite and unilateral lymphadenopathy, while cats themselves, the major reservoir of CSD, are asymptotic carriers, showing longterm bacteremia with antibody formation (1, 16).The number of human clinical cases of CSD has been increasing worldwide. Most cases are diagnosed based on clinical manifestations, the history of contacts with cats, serology (14,20,24,26,28,33) or PCR-based methods for examining the biopsy specimens (2, 10, 28). However, the isolation of the organism from patients is relatively difficult and only a few cases of the organism isolation have been reported worldwide (7,9,18,25), because suitable material is not available, the culture conditions are not appropriate or the organism shows fastidious, cytozoic and slow-growth properties. The isolation and establishment of Bartonella strains are extremely important for both etiological diagnosis and epidemiological and genetical analysis of the isolates. Though many clinical cases of CSD have been reported in Japan (20,24,33), there are to date no available reports of the isolation of B. henselae from human cases in Japan.B. henselae type II was detected in 18% of the isolates from CSD patients in the Netherlands (3), and 94% of cat isolates in Germany (27). In contrast, Maruyama et al. showed that type I is the predominant gene type in domestic cats in Japan (21). However, no data was available for the prevalence of gene type on the isolates from CSD patients in Japan.In this study, the authors describe a typical CSD case and the isolation of B. henselae from the patient in Medicine, Yame General Hospital, Fukuoka, Fukuoka 834-0034, Japan Received September 12, 2003; in revised form, October 27, 2003. Accepted November 20, 2003 Abstract: We isolated Bartonella henselae from an inguinal lymph node of a 36-year-old male patient with cat-scratch disease. The patient had many areas of erythema on his body, swelling of the left inguinal lymph nodes with pain and slight fever. The diagnosis was made on the basis of polymerase chain reaction for B. henselae DNA from the lymph node biopsies and blood sample, and isolation of the organism, histology of the lymph node and serology with an indirect immunofluorescent antibody test. We also analyzed the genome profiles for five strains of 90 isolates from the lymph node by pulsed-field gel electrophoresis after NotI endonuclease digestion. We found two different genomic profiles. These results suggest that the patient had been either co-infected or re-infected with two genetically different strains of B. henselae.

show abstract

mentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

First Isolation of Bartonella henselae Type I from a Cat‐Scratch Disease Patient in Japan and Its Molecular Analysis

Maruyama

Izumikawa

Miyashita

et al. 2004

Microbiology and Immunology

View full text Add to dashboard Cite

show abstract

“…Further typical histopathology findings of granulomas or plump bacilli on Warthin-Starry or similar silver staining (e.g., Steiner) may not be present during the initial inflammatory phase. Additional tests, including PCR-based assays, are now commercially available through multiple laboratories and can be even more sensitive than serologic studies (Matar et al 1999, Sander et al 1999, Murakami et al 2002, Metzkor-Cotter et al 2003. PCR of tissue is specific, but sensitivity again is variable, ranging from 40% to 70%.…”

Section: Discussionmentioning

confidence: 99%

BartonellaOsteomyelitis of the Acetabulum: Case Report and Review of the Literature

Puri

Kreppel

Schlaudecker

2015

Vector-Borne and Zoonotic Diseases

View full text Add to dashboard Cite

Introduction: Bartonella henselae commonly involves the mononuclear phagocyte system (MPS), and its most common presentation is lymphadenitis. Rarely, it can cause isolated osteomyelitis. We present a case of a 3 year old with constitutional symptoms and new onset of limp. Previously reported cases of osteomyelitis due to B. henselae are also reviewed here, keeping the index case in mind. Methods: We conducted a Medline search using MeSH subject headings Bartonella and osteomyelitis, limited to humans. Results: The index case is a 3-year-old female who had a subacute presentation with new-onset leg pain and fever. Subsequent imaging demonstrated osteomyelitis of the acetabulum. Multiple diagnostic attempts were unsuccessful, and the patient did not respond to empiric therapy. Despite indeterminate serology, the diagnosis of Bartonella osteomyelitis was eventually confirmed by PCR on bone biopsy of the lesion. The literature search revealed 48 publications, which were reduced to 28 when limiting articles to the English language and the pediatric population. After a report of 36 pediatric cases in 2007, there have been an additional 12 pediatric cases since 1998. Generally, these patients had a subacute presentation with relatively mild constitutional symptoms. Most commonly, bone involvement occurred as osteolytic lesions of the axial skeleton. Of the total 48 cases reported, only four reported involvement of the axial skeleton. Conclusion: We present the first case, to our knowledge, of pediatric osteomyelitis of the pelvis due to B. henselae with indeterminate serologic and positive PCR results. Bartonella osteomyelitis should be included in the differential diagnosis when typical pathogens are not identified or if the patient is slow to respond to standard therapies. The sensitivity of tissue PCR for Bartonella osteomyelitis is now better than the current gold standard of serology, and new management guidelines may need to reflect this.

show abstract

“…at scratch disease (CSD), an infection which is caused by the Gram-negative bacillus Bartonella henselae, is a zoonotic infection which occurs worldwide and which is associated with diverse clinical manifestations (1)(2)(3). Although the predominant clinical feature at the onset of CSD is a regional lymphadenopathy, atypical manifestations may occur, along with systemic symptoms, such as hepatic-splenic granuloma, endocarditis, encephalopathy, and neuroretinitis (1)(2)(3).…”

mentioning

confidence: 99%

Development of a Highly Specific IgM Enzyme-Linked Immunosorbent Assay for Bartonella henselae Using Refined N -Lauroyl-Sarcosine-Insoluble Proteins for Serodiagnosis of Cat Scratch Disease

et al. 2016

Self Cite

View full text Add to dashboard Cite

The conventional anti-Bartonella henselae IgM enzyme-linked immunosorbent assay (IgM-ELISA) methods for diagnosing cat scratch disease (CSD) remain poor in both sensitivity and specificity. We sought to develop an IgM-ELISA with improved accuracy in the serodiagnosis of CSD by exploring the antigens that are most suitable for an ELISA. We prepared 5 different protein antigens: antigen I (sonicated B. henselae whole-cell antigen), antigen II (N-lauroyl-sarcosine-insoluble antigen), antigen III (processed sarcosine-soluble antigen), and antigen IV and antigen V (sarcosine-insoluble and sarcosine-soluble antigens refined by DEAE-Sepharose Fast Flow ion-exchange chromatography). The IgM antibodies in the sera of 47 patients with clinically suspected CSD (24 definite, 23 suspected) and of 85 healthy individuals were examined by ELISAs using the 5 antigens, and the results were compared with those of an IgM indirect fluorescent antibody assay (IgM-IFA). In a reference panel, which consisted of 5 positive and 5 negative sera, antigen I and antigen III failed to distinguish between the two statuses, whereas the other three antigens succeeded in distinguishing between them. When the cutoff value was set at the 98th percentile of the ELISA index for healthy individuals, the sensitivity of IgM-IFA for the 24 cases of definite CSD was 54%, whereas the sensitivities of the IgM-ELISAs with antigen II, IV, and V were 75%, 83%, and 75%, respectively. The sensitivities of these three IgM-ELISAs for all 47 of the clinically suspected cases were 49%, 64%, and 51%, respectively. In contrast, the sensitivity of IgM-IFA was 28%. These results indicate that the refined sarcosine-insoluble proteins (antigen IV), which possessed the highest specificity among the 5 antigens, are the most appropriate for developing an IgM-ELISA for the highly specific serodiagnosis of CSD.

show abstract

Cat scratch disease: analysis of 130 seropositive cases

Cited by 98 publications

References 22 publications

First Isolation of Bartonella henselae Type I from a Cat‐Scratch Disease Patient in Japan and Its Molecular Analysis

First Isolation of Bartonella henselae Type I from a Cat‐Scratch Disease Patient in Japan and Its Molecular Analysis

BartonellaOsteomyelitis of the Acetabulum: Case Report and Review of the Literature

Development of a Highly Specific IgM Enzyme-Linked Immunosorbent Assay for Bartonella henselae Using Refined N -Lauroyl-Sarcosine-Insoluble Proteins for Serodiagnosis of Cat Scratch Disease

Contact Info

Product

Resources

About