CAT PETR: A Graphical User Interface for Differential Analysis of Phosphorylation and Expression Data

Abstract

Analysis of signal transduction pathways relies on monitoring global changes in cellular response to perturbation or genetic manipulation. Antibody microarray data provides an increasingly viable tool for the monitoring and analyzing high throughput expression and phosphorylation data. However, computational tools designed specifically for the analysis of antibody microarray data are few and far between; forcing researchers to use applications primarily designed for other data types. Here we present CAT PETR (Convenient Analysis Tool for Phosphorylation and Expression Testing), a user friendly web application that provides interactive and publication ready plots for the differential analysis of expression and phosphorylation data collected via antibody microarrays. Our tool is made available as a web application at https://av-gay-ubc.shinyapps.io/CAT-PETR/. The code is publicly available on GitHub (https://github.com/Raif-fl/CAT-PETR) with documentation containing tutorials and datasets.