Castor oil reinforced polymer hybrids for skin tissue augmentation

Muzammil, K. Mohammed; Mukherjee, Dhrubojyoti; Azamthulla, Mohammad; Banala, Venkatesh Teja; Kaamnoore, Devanand; Anbu, J.; Srinivasan, Bharath; Kasture, Gargi Jeevan

doi:10.1080/00914037.2020.1740986

Cited by 7 publications

(7 citation statements)

References 58 publications

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“…Some studies have confirmed its efficacy in treating dry skin, 13,14 while others revealed that topical castor oil could be effective in skin tissue regeneration and reepithelialization. [15][16][17] Piamphongsant T. demonstrated that using a phenol-castor oil component during the peeling process adjuvant with an anti-melasma cream was effective in skin hyperpigmentation conditions. 18 Another study demonstrated that topical, periocular application of castor oil improved blepharitis symptoms such as eyelash matting, eyelid margin thickening, telangiectasia, cylindrical dandruff, madarosis, and lid wiper epitheliopathy.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single‐arm clinical trial

Parvizi,

Saki,

Samimi

et al. 2023

J of Cosmetic Dermatology

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IntroductionInfraorbital hyperpigmentation represents one of the most prevalent conditions in cosmetic dermatology. To treat this condition, many patients prefer natural remedies. This study explored the efficacy of topical castor oil cream in treating patients with infraorbital hyperpigmentation.MethodsWe conducted an exploratory single‐arm clinical trial at the Shahid Faghihi Dermatology Clinic and Molecular Dermatology Research Center of Shiraz University of Medical Sciences, Shiraz, Iran, during 2021–2022. Using the convenience sampling method, we enrolled 25 patients with infraorbital hyperpigmentation. We instructed the patients to apply topical castor oil cream twice daily for 2 months. The darkness, melanin, and erythema levels were evaluated by VisioFace® 1000 D and SkinColorCatch® devices. We used a visual analog scale to assess skin laxity, wrinkles, and patient satisfaction. Data analysis was done with Stata version 14.2.ResultsThe data of 22 patients with a mean age of 40.92 ± 7.33 years were analyzed. The VisioFace® scores decreased significantly by the end of the study [right eyes: mean difference (MD): ‐5.63 (95% CI: −7.12 to −4.15), p < 0.001; left eyes: MD: ‐5.91 (95% CI: −7.46 to −4.36), p < 0.001]. Moreover, castor oil cream significantly reduced the melanin level, wrinkles, and skin laxity in the infraorbital region (p < 0.05).ConclusionsCastor oil cream seems to be an effective alternative for treating infraorbital hyperpigmentation. Randomized clinical trials are needed to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single‐arm clinical trial

Parvizi,

Saki,

Samimi

et al. 2023

J of Cosmetic Dermatology

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“…The result analysis indicated the effect of hydroxyapatite and zinc on the composite where Ra characterizes the departures of the roughness profile from the mean line and Rq is the parameter corresponding to Ra (44). The mean roughness and root mean square roughness indicated that the surface of the composite materials is not very rough (20). There could have been a neutralization of hydrophobic hydroxyapatite making the surface rough and hydrophilic zinc extending the surface smoother (the surface without zinc had a higher value of Ra and Rq).…”

Section: Vertical Scanning Interference Microscopy and Scanning Elect...mentioning

confidence: 99%

“…To interpret the surface roughness properties and to investigate the topographical characteristics of the developed nanocomposites, 3D topographical maps using vertical scanning interference microscopy (Non-contact 3D Surface Profiler, Talysurf CCI Lite, MNCF, CeNSE, IISc, Bangalore) were obtained from the developed composite materials (20).…”

Section: Vertical Scanning Interference Microscopymentioning

confidence: 99%

Sodium alginate cross-linked hydroxypropyl methylcellulose/hydroxyapatite nano biomaterial mediated with zinc to promote bone tissue healing

Rudraradhya,

Teja,

Mukherjee

2023

Preprint

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The present study aimed to develop a composite material using sodium alginate and hydroxypropyl methylcellulose in combination with hydroxyapatite. The composite was doped with zinc and developed into a nanocomposite by using ionic gelation and solvent precipitation methods. The prepared nanocomposite was characterized by scanning electron microscopy, atomic force microscopy, dynamic light scattering, FTIR, and XRD studies. In vivo pharmacological studies were carried out to establish the bone targeting and bone tissue regeneration efficacy of the developed nanocomposite. The nanocomposite was checked for cell toxicity by performing an MTT assay using MG63 cell line and the molecular mechanism of targeting efficiency was assessed by in silico evaluation method. The results of the study confirmed the polymeric interlinking in the nanocomposite and the successful preparation of a composite material by using biodegradable excipients. SEM and AFM studies indicated that the nanocomposite was within the 80-200 nm size range. MTT assay indicated that the developed nanocomposite was not cytotoxic and well tolerated by the MG63 cell line. In vivo studies in validation with molecular docking evaluation suggested that the nanocomposite was effectively targeted to the bone as well as had osteogenesis properties by following a mechanism whereby it could effectively block Farnesyl Diphosphate Synthetase in the mevalonate pathway which is essential for inhibiting the osteoclastic activity and promoting osteogenesis.

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“…Therefore, such systems can be a good candidate for skin tissue regeneration and wound healing applications. [158].…”

Section: Antibacterial Surfacesmentioning

confidence: 99%

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

Demirci¹,

Niedźwiedź²,

Kantor-Malujdy³

et al. 2021

Preprint

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Novel bio-inspired materials have gained recently great attention, especially in medical applications. Applying sophisticated design and engineering methods, various polymer-polymer hybrid systems with outstanding performance have been developed in last decades. Hybrid systems composed of bioelastomers and hydrogels are very attractive due to their high biocompatibility and elastic nature for advanced biomaterials used in various medical applications such as drug delivery systems and scaffolds for tissue engineering. Herein, we describe the advances in current state-of-the-art design, properties and applications of polymer-polymer hybrid systems in medical applications. Bio-inspired functionalities, including bioadhesiveness, injectability, antibacterial properties and degradability applicable to advanced drug delivery systems and medical devices will be discussed in a context of future efforts towards development of bioinspired materials.

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Castor oil reinforced polymer hybrids for skin tissue augmentation

Cited by 7 publications

References 58 publications

Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single‐arm clinical trial

Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single‐arm clinical trial

Sodium alginate cross-linked hydroxypropyl methylcellulose/hydroxyapatite nano biomaterial mediated with zinc to promote bone tissue healing

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

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