Castor Bean Allergy as Cross-Reactive Hypersensitivity to the Spurges (Euphorbiaceae): Absence of Reaction to Chlorogenic Acid in Primary Allergy to Castor Beans

Ll, Layton; Panzani, R; Fc, Greene

doi:10.1159/000229423

Cited by 13 publications

(3 citation statements)

References 11 publications

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“…This indicates that the absence of allergic reactions after the oral intake of CGA-containing foods might be due to the rapid degradation of CGA in the digestive system . In contrast, given that CGA administration does not induce anaphylactic reactions to castor bean, castor-bean-allergic patients exhibit no skin reaction to CGA, and anaphylaxis in response to the spurges is observed in all castor-bean-allergic patients, Layton et al proposed that the actual allergen in castor bean and green coffee is the proteins rather than CGA. − Currently, there is no definitive conclusion regarding the allergenic activity and mechanism of CGA. The proposed mechanisms underlying sensitivity to CGA mainly included (i) induction of IgE-mediated anaphylaxis through a combination of CGA with serum proteins as a hapten, (ii) elicitation of the plasmacyte reaction via stimulation of the mononuclear phagocyte system, and (iii) induction of an anaphylactoid reaction without initiation of the immune system .…”

Section: Gut Metabolites Of Cgas In Cvdmentioning

confidence: 99%

Chlorogenic Acids in Cardiovascular Disease: A Review of Dietary Consumption, Pharmacology, and Pharmacokinetics

Chen

et al. 2020

J. Agric. Food Chem.

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Chlorogenic acids (CGAs) have gained considerable attention as pervasive human dietary constituents with potential cardiovascular-preserving effects. The main sources include coffee, yerba mate, Eucommia ulmodies leaves, and Lonicerae Japonicae Flos. CGA consumption can reduce the risks of hypertension, atherosclerosis, heart failure, myocardial infarction, and other factors associated with cardiovascular risk, such as obesity and type 2 diabetes. This review recapitulates recent advances of CGAs in the cardiovascular-preserving effects, pharmacokinetics, sources, and safety. Emerging evidence indicates that CGAs exhibit circulatory guarding properties through the suppression of oxidative stress, leukocyte infiltration, platelet aggregation, platelet–leukocyte interactions, vascular remodeling, and apoptosis as well as the regulation of glucose and lipid metabolism and vasodilatory action in the cardiovascular system. CGAs exert these effects by acting on complex signaling networks, but the global mechanisms are still not clear. The oral bioavailability of CGA is poor, and there is a potential sensitization concern about CGA. The bioactive metabolites, systematic toxicity, and optimized structure are needed for further identification.

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Section: Gut Metabolites Of Cgas In Cvdmentioning

confidence: 99%

Chlorogenic Acids in Cardiovascular Disease: A Review of Dietary Consumption, Pharmacology, and Pharmacokinetics

Chen

et al. 2020

J. Agric. Food Chem.

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“…Later investigations reported that patients allergic to green coffee beans reacted with citrus fruits and castor beans (Freedman, Krupey & Sehon, 1961;Freedman et aL, 1962Freedman et aL, , 1964bFreedman, Shulman & Krupey, 1964a;Siddiqi & Freedman, 1963) and that this cross-reaction was due to the presence of chlorogenic acid in these different vegetable products (Freedman et al, 1961(Freedman et al, , 1964b. Contrary to these findings are reports which suggest that the green coffee bean protein rather than chlorogenic acid is the major allergen in the green coffee bean (Layton et al, 1961;Layton, Greene & Panzani, 1965a;Layton, Panzani & Greene, 1963;Layton et al, 1965b). The current investigation was undertaken to analyse the allergenic potential of suspect allergens, to assess possible cross-reactivity between coffee and castor bean allergens and to purify coffee allergens.…”

Section: Introductionmentioning

confidence: 97%

Extraction and analysis of coffee bean allergens

Lehrer

Karr

Salvaggio

1978

Clin Experimental Allergy

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Summary Workers in the coffee industry can develop occupational allergic disease upon exposure to dust associated with coffee manufacturing. Since controversy exists as to the source or chemical nature of these allergens, the mouse model of reaginic antibody production was used to assess the potential sources of allergens in samples obtained from a local coffee manufacturing plant. Mice were immunized with extracts of coffee dust and beans and the resulting reaginic antibody response determined by the passive cutaneous anaphylaxis reaction. Cross‐reacting allergens were detected in samples of coffee dust, cleaner can debris and green coffee beans, but not in chaff or roasted coffee beans. None of the allergens detected in coffee samples cross‐reacted with extracts of castor beans, although these extracts contained the potent castor bean allergen. Green coffee bean allergens partially purified by gel filtration were heterogeneous with respect to molecular size, although quite similar in their reactivity with reaginic antiserum. These results suggest that the green coffee bean is the major source of allergen in coffee manufacturing plants. This allergen is heterogeneous with respect to size and heat lability, and is immunochemically different from the castor bean allergen.

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“…Chlorogenic acid (CGA) is a ubiquitous component in most Chinese herbal injections, also usually employed as a typical marker to control the quality of TCM ( 8 ), such as Shuang-Huang-Lian (SHL) injection (according to the Pharmacopeia of China, 2005). This field remains problematic ( 9 , 10 ) though the allergenicity has constantly counted as the primary factor leading to adverse effects of CGA ( 11 , 12 ). On the other hand, CGA in lower concentrations eliminated hydroxyl radical and superoxide in vitro although CGA at higher concentrations produced radicals and served as a pro-oxidant, as previously reported ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic acid in the oxidative stress injury triggered by Shuang‑Huang‑Lian injection

Xiao

Yao

et al. 2018

Exp Ther Med

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Injections of Chinese herbs are a novel approach to prepare traditional Chinese medicines. However, as injections of Chinese herbs have been extensively used, adverse drug reactions (ADRs) have been on the increase. Additionally, the mechanism for injections of Chinese herbs remains unclear. This study explored the potential role played by chlorogenic acid (CGA) in initiating oxidative stress injury triggered by the utilization of injections of Chinese herbs and the underlying mechanism. A total of 90 male Wistar rats were raised for varying periods by using Shuang-Huang-Lian (SHL) injection or CGA in diverse dosages. Western blot analysis examined the expression of nicotinamide adenine dinucleotide phosphate oxidase subunits, spectrophotometry was used to examine the activity taken by catalase, ELISA was used to examine the concentrations of inflammatory factors in serum, and intravital microscopy was employed to examine the microcirculation. The results showed that the excessive peroxide production induced by CGA in high-dose or SHL in the venule walls may well be through nicotinamide adenine dinucleotide phosphate oxidase along with a decline in the activity of catalase, and led to imbalance of basal levels of pro-(TNF-α) and anti-(IL-10) inflammatory cytokines. On the basis of the aforementioned results, the mechanism hidden behind the adverse effects of CGA induced by irrational use of Chinese herbal injection can be identified from a deeper perspective.

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Castor Bean Allergy as Cross-Reactive Hypersensitivity to the Spurges (Euphorbiaceae): Absence of Reaction to Chlorogenic Acid in Primary Allergy to Castor Beans

Cited by 13 publications

References 11 publications

Chlorogenic Acids in Cardiovascular Disease: A Review of Dietary Consumption, Pharmacology, and Pharmacokinetics

Chlorogenic Acids in Cardiovascular Disease: A Review of Dietary Consumption, Pharmacology, and Pharmacokinetics

Extraction and analysis of coffee bean allergens

Chlorogenic acid in the oxidative stress injury triggered by Shuang‑Huang‑Lian injection

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