Castleman's tumours and production of autoantibody in paraneoplastic pemphigus

Wang, Liangchun; Bu, Dingfang; Yang, Yanling; Chen, Xixue; Zhu, Xuejun

doi:10.1016/s0140-6736(04)15539-6

Cited by 120 publications

(121 citation statements)

References 22 publications

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“…Furthermore, epitope spreading leading to transition from an initial, mucosal dominant type with only anti-Dsg3 antibodies, to an anti-Dsg1 (27.3 U/l) and anti-Dsg-3 (35.6 U/l) positive form had occurred. A similar beneficial effect of tumor ablation has recently also been reported in the case of Castleman's tumor, a rare lymphoproliferative disease that is sometimes associated with paraneoplastic pemphigus [12]. Our data provide further evidence for the important role of autoantibodies in the pathogenesis of myasthenia gravis and paraneoplastic skin diseases in thymoma patients and document the improvement of the associated diseases after radical treatment of the thymoma with concomitant immunosuppressive treatment.…”

Section: Letter To the Editorssupporting

confidence: 86%

Myasthenia gravis, paraneoplastic pemphigus and thymoma, a rare triade

Winkler

Strnad

Meier³

et al. 2007

J Neurol

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Section: Letter To the Editorssupporting

confidence: 86%

Myasthenia gravis, paraneoplastic pemphigus and thymoma, a rare triade

Winkler

Strnad

Meier³

et al. 2007

J Neurol

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“…The subendothelial cell swelling on glomerular capillaries in our case might implicate that the VEGF pathway was modulated to maintain glomerular capillary walls. Other circulating factors, which can cause FSGS, could be possibly produced by polyclonal B cell activation [17].…”

Section: Discussionmentioning

confidence: 99%

Focal segmental glomerulosclerosis associated with cutaneous and systemic plasmacytosis

et al. 2017

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Cutaneous and systemic plasmacytosis (CSP) is a rare lymphoproliferative disorder that mainly affects middle-aged Asian individuals. Although Castleman disease is often complicated with various renal involvements, glomerulonephritis associated with CSP, which is considered as a variant of Castleman disease, is rare. This report presents the case of a 41-year-old Japanese man with nephrotic syndrome associated with CSP. Renal biopsy findings showed focal segmental glomerulosclerosis (FSGS) and diffusely mild segmental mesangial proliferation. Plasma cell infiltration in the interstitium was not observed. Electron microscopic findings showed diffuse foot process effacement, localized involvement of subendothelial space widening with amorphous materials, and endothelial cell swelling. Lymph node biopsy findings denied Castleman disease. His skin regions and proteinuria were successfully treated with prednisolone and cyclosporine. The causal relationship between CSP and FSGS is unknown. However, increased serum levels of IL-6 and VEGF and decreased VEGF expression in the podocyte may contribute to renal lesions in patients with CSP. To our best knowledge, this is the first case of a patient with FSGS associated with CSP.

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“…117 There is some evidence that the antibodies that recognize multiple antigens in the epidermis and ultimately cause the disease may be produced by the tumor. 123 The antigens targeted appear to cross react with the specific rearrangements of the IGHV gene. Other authors have suggested epitope spreading as the mechanism, i.e.…”

Section: Paraneoplastic Pemphigusmentioning

confidence: 99%