Castleman's disease of the neck: a case report

Pasha, Hamdan Ahmed; Siddiqui, Moghira Iqbal; Wasif, Muhammad

doi:10.5455/jpma.13110

Cited by 1 publication

(2 citation statements)

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“…The incidence and prevalence of CD has become difficult to evaluate due to its rare occurrence in the general population, and it affects both sexes equally[ 2 ]. UCD is usually found to have a peak incidence in the second to fourth decades of life[ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Just like the patient in our manuscript, in some reports[ 13 - 15 ], no recurrence was found either clinically or radiologically that underwent surgical excision. Moreover, surgical excision was seen to decrease the mortality rates (17.6% to 3.8%) in UCD in a systematic review of 404 published cases[ 2 , 16 ]. In contrast, MCD had a poor response to surgery and worse prognosis when compared to UCD.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Unicentric Castleman disease was misdiagnosed as pancreatic mass: A case report

Zhai¹,

Zhu²,

Zhou³

et al. 2022

WJCC

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BACKGROUND Castleman’s disease (CD) is a lymphatic proliferative disorder of unknown cause and is rarely seen clinically. It has been divided into unicentric and multicentric types. Unicentric CD (UCD) occurs as a solitary enlarged mass and mediastinal lymph nodes are the most common site. Surgical excision has proven to be curative for UCD. Multicentric CD (MCD) appears as a systemic disease with peripheral lymphadenopathy. MCD had a poor response to surgery and monoclonal antibodies with rituximab have become a research hotspot. CASE SUMMARY A 44-year-old woman presented with a pancreatic mass during routine physical examination. She had no obvious symptoms, such as fever, abdominal pain, abdominal distension, or jaundice. Ultrasound examination indicated a hypoechoic mass between the body of the pancreas, left lobe of the liver and stomach. It had a clear boundary, irregular shape, uneven echo, and no obvious blood flow signals. To clarify the diagnosis, contrast-enhanced ultrasound examination was performed, which showed a benign pancreatic lesion. Neuroendocrine or solid pseudopapillary tumor was a possible diagnosis. The patient underwent further contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging, which were suggestive of solid pseudopapillary tumor or neuroendocrine tumor. All the examinations failed to give a definitive diagnosis, and the patient underwent surgery. The final pathological and immunohistochemical results showed that the mass was CD. CONCLUSION This case highlights when lymphadenopathy is encountered clinically, CD should be considered and a biopsy should be performed.

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Section: Discussionmentioning

confidence: 99%