Castleman's disease in childhood: report of three cases and review of the literature

Farruggia, Piero; Trizzino, Antonino; Scibetta, Nunzia; Cecchetto, Giovanni; Guerrieri, Patrizia; dʼAmore, Emanuele S.G.; D’Angelo, Paolo

doi:10.1186/1824-7288-37-50

Cited by 45 publications

(51 citation statements)

References 43 publications

(77 reference statements)

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“…The prevalence of the disease in all ages is estimated to be one in 30,000-100,000, but the prevalence in the pediatric population is unknown (34). About 100 case reports of pediatric Castleman disease have been published in the literature (35). The disease most commonly arises in the thorax but may involve the mesentery.…”

Section: Castleman Diseasementioning

confidence: 98%

Solid Tumors of the Peritoneum, Omentum, and Mesentery in Children: Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Em¹,

Dm²,

Am³

et al. 2015

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Intraperitoneal solid tumors are far less common in children than in adults, and the histologic spectrum of neoplasms of the peritoneum and its specialized folds in young patients differs from that in older patients. Localized masses may be caused by inflammatory myofibroblastic tumor, Castleman disease, mesenteric fibromatosis, or other mesenchymal masses. Inflammatory myofibroblastic tumor is a mesenchymal tumor of borderline biologic potential that appears as a solitary circumscribed mass, possibly with central calcification. Castleman disease is an idiopathic lymphoproliferative disorder that appears as a circumscribed, intensely enhancing mass in the mesentery. Mesenteric fibromatosis, or intra-abdominal desmoid tumor, is a benign tumor of mesenchymal origin associated with familial adenomatous polyposis. Mesenteric fibromatosis appears as a mildly enhancing, circumscribed solitary mass without metastases. Diffuse peritoneal disease may be due to desmoplastic small round cell tumor (DSRCT), non-Hodgkin lymphoma, or rhabdomyosarcoma. DSRCT is a rare member of the small round blue cell tumor family that causes diffuse peritoneal masses without a visible primary tumor. A dominant mass is typically found in the retrovesical space. Burkitt lymphoma is a pediatric tumor that manifests with extensive disease because of its short doubling time. The bowel and adjacent mesentery are commonly involved. Rhabdomyosarcoma may arise as a primary tumor of the omentum or may spread from a primary tumor in the bladder, prostate, or scrotum. Knowledge of this spectrum of disease allows the radiologist to provide an appropriate differential diagnosis and suggest proper patient management.

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Section: Castleman Diseasementioning

confidence: 98%

Solid Tumors of the Peritoneum, Omentum, and Mesentery in Children: Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Em¹,

Dm²,

Am³

et al. 2015

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“…Tek-bölgeli CH'da tam cerrahi çıkarma, hem hyalin vasküler hem de plazma hücreli tipte çoğunluk-la tedavi sağlar (13)(14)(15)(16)(17)(18)(19) . Olguların %90'dan fazlasının tam cerrahi çıkarmayla tedavi edildiği, çok-bölgeli CH'lilerde ise kemoterapi ve/veya radyoterapi gerekebileceği bildirilmiştir (12) .…”

Section: Discussionunclassified

“…Olguların %90'dan fazlasının tam cerrahi çıkarmayla tedavi edildiği, çok-bölgeli CH'lilerde ise kemoterapi ve/veya radyoterapi gerekebileceği bildirilmiştir (12) . Radyoterapi ve kemoterapinin tam iyileşme sağlamasalar da tedaviye yardımcı oldukları kabul edilmektedir (4,6,15) .…”

Section: Discussionunclassified

Single-Region Castleman's Disease: Case report

Eker¹,

Güvenç²,

Sander³

et al. 2017

tcdd

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“…About 100 pediatric cases have been published in the literature, mostly reported as a localized and benign condition. 6,7,[13][14][15] Intrathoracic locations of the unicentric tumor in children are not as frequent as in adult cases (33% vs. 70%, respectively), and mesenteric location of the disease is more often encountered in children. 7 Head and neck localizations are found only in 14% of the pediatric cases.…”

Section: Discussionmentioning

confidence: 99%

“…Paraneoplastic and autoimmune entities are not uncommon in this disorder. 7,11,13,[16][17][18][19][20] There is an increased incidence of CD in patients with HIV. 21,22 The HHV-8 is associated with nearly all of the HIV-associated CD cases and nearly 50% of non-HIV cases.…”

Section: Discussionmentioning

confidence: 99%

Multicentric Plasma Cell Type of Castleman Disease in a Child

Karapınar

Tüfekçi

Gözmen

et al. 2013

Journal of Pediatric Hematology/Oncology

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Multicentric plasma cell variant of Castleman disease (CD) has rarely been reported and the optimal therapeutic approach is unknown, especially in childhood. In this case report, we discuss the case of a 7-year-old boy with multicentric plasma cell variant of CD, who presented with cervical lymphadenopathies, autoimmune hemolytic anemia, bone marrow insufficiency, pulmonary, renal, hepatic, and gastrointestinal involvement, emphasizing the difficulty in diagnosis and treatment approach.

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Castleman's disease in childhood: report of three cases and review of the literature

Cited by 45 publications

References 43 publications

Solid Tumors of the Peritoneum, Omentum, and Mesentery in Children: Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Solid Tumors of the Peritoneum, Omentum, and Mesentery in Children: Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Single-Region Castleman's Disease: Case report

Multicentric Plasma Cell Type of Castleman Disease in a Child

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