Castleman disease of the thorax: radiologic features with clinical and histopathologic correlation.

McAdams, H. Page; Rosado-de-Christenson, Melissa L.; Fishback, N.; Templeton, Philip A.

doi:10.1148/radiology.209.1.9769835

Cited by 152 publications

(137 citation statements)

References 21 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…Castleman's disease may occur at any site with lymph nodes and extranodal areas, and most frequently involves the mediastinum, abdomen, neck, and axillae, and less commonly, the retroperitoneum, mesentery, and pelvis, 7,12,16,17,21,24,31,36) although extranodal lesions have also occurred in the lungs, thymus, pericardium, and vulva. 16) Intracranial involvement is extremely rare, with only 12 previously reported cases.…”

Section: Fig 1 Preoperative Computed Tomography Scansmentioning

confidence: 99%

Intracranial Localized Castleman's Disease-Case Report-

Matsumura¹,

Nakasu

Tanaka

et al. 2005

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 68-year-old woman presented with generalized clonic seizure following a 2-month history of initiative loss, incoherent speech, headache, and left hemiparesis. No systemic signs or symptoms were seen and laboratory studies were within normal range. Computed tomography and magnetic resonance imaging demonstrated a well-delineated small mass with homogeneous enhancement in the right parietal convexity, associated with unusually extensive perifocal edema compared to the size of the mass. Cerebral angiography showed a faint stain fed by the middle meningeal artery. These imaging features were very similar to those of meningioma. Full recovery from the symptoms was achieved by total removal of the lesion and no recurrence was found after 3 years. Histological examination identified the hyaline-vascular type of angiofollicular lymph node hyperplasia (Castleman's disease). Castleman's disease involving the central nervous system is rare, with only 12 previous cases, but should be considered in the diagnosis of intracranial meningeal tumors. The treatment of choice for localized Castleman's disease is complete surgical resection, which is curative in most of the cases.

show abstract

Section: Fig 1 Preoperative Computed Tomography Scansmentioning

confidence: 99%

Intracranial Localized Castleman's Disease-Case Report-

Matsumura¹,

Nakasu

Tanaka

et al. 2005

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

show abstract

“…12) Although the causes of these diseases are unknown, various pathogenetic mechanisms involving inflammation, autoimmunity disorders, and infection have been proposed. [2][3][4][5] We eventually concluded that our patient's pericoronary pseudotumor was caused by H. cinaedi-induced inflammation leading to formation of a tumor-like lesion. There are published case reports describing pseudoneoplasms that occurred secondary to infection with Mycobacterium avium-intracellulare complex, Escherichia coli, Klebsiella, Pseudomonas, and Helicobacter pylori.…”

Section: Discussionmentioning

confidence: 80%

“…1) Possible pathogenetic mechanisms include inflammation, autoimmune disorders, and infections. [2][3][4][5] Helicobacter cinaedi is commonly isolated from compromised patients; however, there are increasing reports of this organism infecting immunocompetent patients. [6][7][8] H. cinaedi infection is reportedly associated with cardiovascular disease.…”

mentioning

confidence: 99%

Pericoronary Pseudotumor Caused by Helicobacter Cinaedi

et al. 2014

View full text Add to dashboard Cite

SummaryCardiac tumors and tumor-like lesions are uncommon; most are true neoplasms. We here report a case of a pericoronary tumor-like lesion surrounding the right coronary artery in a 39-year-old man who presented with fever and chest pain. Although clarithromycin was administered for 1 week, his fever persisted. Helicobacter cinaedi (H. cinaedi) was isolated from blood cultures and found to be sensitive to ceftriaxone. A computed tomography scan showed a tumor-like lesion with no 18 F-fluorodeoxyglucose uptake surrounding the right coronary artery. After administration of ceftriaxone, the tumor-like lesion diminished in size according to meticulous computed tomography examinations. We therefore concluded that it was caused by H. cinaedi infection. The patient has been followed up closely for 1 year and remains asymptomatic. (Int Heart J 2014; 55: 463-465) Key words: Cardiac tumor, PET-CT P rimary cardiac tumors are uncommon; most are neoplasms. However, some tumor-like lesions are reactive, pseudoneoplastic masses. 1) Possible pathogenetic mechanisms include inflammation, autoimmune disorders, and infections.2-5) Helicobacter cinaedi is commonly isolated from compromised patients; however, there are increasing reports of this organism infecting immunocompetent patients. [6][7][8] H. cinaedi infection is reportedly associated with cardiovascular disease.9,10) We here report a case of a pericoronary pseudotumor caused by H. cinaedi. Case ReportA 39-year-old man presented to another institution with fever and chest pain. His white blood cell count was 19,440/ μL, and serum C-reactive protein concentration 11.2 mg/dL. Pneumonia was suspected and 400 mg of clarithromycin per day was administered orally for 1 week. However, his fever persisted and H. cinaedi was isolated from blood cultures, after which 2 g per day of intravenous ceftriaxone was substituted for clarithromycin for 2 weeks. Because infective endocarditis was suspected, transthoracic echocardiography was performed. This showed a mass on the lateral side of the right atrium and ventricle. A computed tomography (CT) scan showed a 5.8 × 4.2 cm tumor-like lesion around the right coronary artery (Figure 1). After he had received ceftriaxone for 2 weeks, the results of blood examinations returned to within normal limits and he was referred to our hospital for a suspected cardiac tumor.On presentation to our hospital, his physical examination was normal. White blood cell count was 4,720/μL with a normal differential count and the C-reactive protein concentration was within normal limits. Biochemical data, including serum immunoglobulin concentrations, were unremarkable. Tumor markers such as carcinoembryonic antigen, cancer antigens 19-9 and 125, α-fetoprotein, squamous cell carcinoma antigen, interleukin-6, and soluble interleukin-2R were all within normal limits. There was no evidence of immune deficiency and HIV serology was negative. Chest X-ray films showed no cardiomegaly or any other abnormalities. Electrocardiography showed normal sinus rhythm with...

show abstract

“…McAdams and colleagues published series of 30 case with Castleman's disease in 1998 (8). Several cases were reported in which the mass was invading contiguous structures or associated with multiple enlarged lymph nodes.…”

Section: Discussionmentioning

confidence: 99%