Abstract:Castleman disease represents a group of polyclonal lymphoproliferative entities. Based on clinicopathological associations, the disease can now be clinically divided into two subtypes: unicentric disease and multicentric disease. The multicentric Castleman disease (MCD) involves multiple lymph nodes from different anatomical sites and represents the other 25% of cases, occurring in 5 out of 1 million patients. MCD is multifactorial and can be subdivided according to its clinical association. It is known that i… Show more
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