Casting a Wide Net: HIV Drug Resistance Monitoring in Pre-Exposure Prophylaxis Seroconverters in the Global Evaluation of Microbicide Sensitivity Project

Abstract

Monitoring for HIV drug resistance (HIVDR) within preexposure prophylaxis (PrEP) programs is feasible, and samples collected through these methods can be used to provide early indicators of the risk of HIVDR among PrEP users. n Additional information beyond clinical trial data is needed on the risk of HIVDR in large-scale PrEP rollout programs, where HIV testing occurs less frequently and adherence support strategies are less robust.n Laboratory capacity remains a major obstacle to establishing HIVDR monitoring systems in low-and middle-income countries.