Castelman disease of the parotid gland: An unusual entity

Abstract

Castleman disease (CD) is a benign lymphoepithelial disorder characterised by abnormal growth of a lymph node. This disease may be seen anywhere along the lymphatic chain but it usually occurs in the mediastinum. Two clinical types (localised and generalised) and three histopathological types (hyaline vascular, plasma cell, and mixed) have been described. We present a case of a 35-year-old female patient with parotid CD of the hyaline-vascular type as an extremely rare entity. We also discuss recent updates on this disease.

Castleman Disease of the Parotid Gland: A Report of a Case

“…The multicentric type of CD is more aggressive and it has a predisposition to men in their third to fifth decades of life. The unicentric (localized) form, as the name suggests, has a more benign process [ 5 ]. It is usually asymptomatic with just a palpable enlarged lymph node.…”

Castleman's Disease Mimicking a Parotid Gland Tumor

“…1 CD of the parotid gland is an extremely rare entity, with only 26 cases reported in the English literature. 5,6 CD has 2 histologic types; hyaline vascular and plasma cell. Cases with mixed histological features have also been reported.…”

“…Radiological findings are beneficial, but not diagnostic. 5 CD is a heterogeneous disorder that can represent a continuous spectrum of disease or several different diseases all together; clinically it might be asymptomatic or could be lethal, The final diagnosis could be achived by histopathological evaluation, The treatment has to be surgery which appears to be curative in local lesions; in inoperable or systemic variants the treatment is radiation therapy and chemotherapy. 10 It is important to remember this entity for enlarged lymph nodes even in extreme localizations.…”

Castleman Disease; A Rare Mass of Neck

“…Unicentric type is localized form of disease that has benign subtypes. (7). This disease is usually characterized by a large lymph node which is Abant Med J 2020;9(2):50-53 52 generally asymptomatic.…”