Castelli Index and estimative of LDL-c particle size may still help in the clinical practice?

Barbalho, Sandra Maria; Tofano, Ricardo José; Bechara, Marcelo Dib; Quesada, Karina; Coqueiro, Daniel Pereira; Mendes, Claudemir Gregório

doi:10.5530/jcdr.2016.2.6

Cited by 11 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other dyslipidaemic characteristics including the Castelli Risk Index 1 (total cholesterol/HDL-c), Castelli Risk Index 2 (LDL-c/HDL-c) and atherogenic index of plasma (logarithm of triglyceride/HDL-c) were calculated where adequate data were available and considered to be elevated when greater than 4.4, 2.5 and 0.5, respectively. 13 14 Unfortunately, data on alcohol and tobacco use were not routinely collected and therefore not available. The proportion of the study population who were aware of their hypertension and diabetic status was also determined.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and correlates of traditional risk factors for cardiovascular disease in a Nigerian ART-naive HIV population: a cross-sectional study

et al. 2018

View full text Add to dashboard Cite

ObjectivesHIV infection environment presents a classic example of the interplay between infectious diseases and non-communicable diseases (NCDs). Traditional cardiovascular disease (CVD) risk factors abound in the HIV population even before initiation of antiretrovirals (ARVs) and predispose them to the development of stroke and myocardial infarction. This work focuses on determining the prevalence of traditional CVD risk factors among ARV-naive HIV individuals in southern Nigeria.MethodsThis was a cross-sectional study of ARV-naive patients initiating care at the University of Uyo Teaching Hospital HIV clinic cohort to determine the prevalence and correlates of hypertension, diabetes mellitus (DM), obesity and dyslipidaemia.ResultsThe sample consisted of 4925 assessed for hypertension, 5223 for obesity, 1818 for DM and 926 for dyslipidaemia. Hypertension prevalence was 26.7% (95% CI 25.5% to 28.0%) with a male preponderance (p=0.02). DM was found in 5.6% (95% CI 4.5% to 6.7%), obesity in 8.3% (95% CI 7.6% to 9.1%) and dyslipidaemia in 29.1% (95% CI 26.1% to 32.1%) with a high prevalence of low high-density lipoprotein-c (42.6%). Hypertension was independently associated with age (OR 1.04 (95% CI 1.03 to 1.05), p<0.001) and body mass index (BMI) (OR 1.06 (95% CI 1.03 to 1.08), p<0.001), obesity with age (OR 1.02 (95% CI 1.01 to 1.03), p<0.001), male gender (OR 0.38 (95% CI 0.29 to 0.49), p<0.001) and CD4 count (OR 2.63 (95% CI 1.96 to 3.53), p<0.001) while dyslipidaemia was associated with BMI (OR 1.05 (95% CI 1.01 to 1.10), p=0.03).ConclusionThe prevalence of traditional CVD risk factors is high in this ART-naive HIV population. An integrated approach of HIV and NCD screening/treatment may be relevant for centres in sub-Saharan Africa.

show abstract

Section: Methodsmentioning

confidence: 99%

Prevalence and correlates of traditional risk factors for cardiovascular disease in a Nigerian ART-naive HIV population: a cross-sectional study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Many risk factors play fundamental roles in dyslipidemias, including smoking, obesity, physical inactivity, high blood pressure, insulin resistance, and environmental and genetic influences. 1 - 5…”

Section: Introductionmentioning

confidence: 99%

“…The etiology of MS involves genetic, metabolic and environmental factors and it usually manifests with insulin resistance and abnormal values of HDL-c, triglycerides (TG), waist circumference (WC), blood pressure, and C-reactive protein (CRP), in addition to obesity. 1…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

HDL-C and non-HDL-C levels are associated with anthropometric and biochemical parameters

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background Dyslipidemias are associated with atherosclerosis and cardiovascular diseases. Recently, non-high-density lipoprotein cholesterol (non-HDL-c) has emerged as a new target for assessment and prediction of risk of cardiovascular disease (CVD) and is closely associated with atheroma plaque progression. Objectives To evaluate associations between HDL-c and non-HDL-c levels and anthropometric and biochemical parameters and with the Castelli risk indexes I and II. Methods 300 randomly selected people were subdivided into two groups: patients with normal values for non-HDL-c and patients with altered values for non-HDL-c. These parameters were analyzed for associations with glycemia, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-c), Castelli Index I (CI-I), Castelli Index II (CI-II), waist circumference (WC), body mass index (BMI) and presence of metabolic syndrome (MS). Results Glycemia, TC, TG, LDL-c, CI-I, CI-II, WC and BMI were all significantly different between subjects with normal and altered values of HDL-c and non-HDL-c. TC and WC both exhibited significantly higher values among patients with abnormal non-HDL-c when compared to patients with abnormal HDL-c. A significant difference was observed in occurrence of MS among patients with altered values of HDL-c and non-HDL-c. Conclusions Our results show that both HDL-c and non-HDL-c are associated with insulin resistance, dyslipidemia, atherogenic indices, and obesity. There is therefore a need for randomized clinical intervention trials examining the potential role of non-HDL-c as a possible primary therapeutic target.

show abstract

“…The Castelli Indexes I and II were calculated, using TC/HDL-c and LDLc/HDL-c ratios, respectively. 13 The presence of MS was evaluated according to NCEP ATP III, which requires the presence of any three of the following five conditions: abdominal obesity (WC ≥ 102 cm in men and ≥ 88 cm in women); hyperglycemia (fasting plasma glucose ≥ 100 mg/dL); serum HDL-c ≤ 50 mg/dL in women and ≤ 40 mg in men; serum triglycerides (TG) ≥ 150 mg/dL (1.7 mmol/L); and BP ≥ 130/85 mmHg). 1 Other parameters were also evaluated, such as smoking and alcohol consumption.…”

Section: Anthropometric and Biochemical Analysismentioning

confidence: 99%

<p>Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk</p>

Togfano

Pescinni-Salzedas

Chagas

et al. 2020

DMSO

Self Cite

View full text Add to dashboard Cite

Aim: To evaluate the association between parameters of hyperferritinemia (HF) and metabolic syndrome (MS) in patients at cardiovascular risk. Patients and Methods: This is a cross-sectional analytical observational study that included 269 patients who attended a cardiology unit. Biochemical and anthropometric parameters were evaluated to identify the presence of HF and MS. The presence of MS was evaluated according to NCEP ATP III. Biochemical parameters (glycemia, triglycerides, HDL-c) were assessed according to the manufacturer's protocols. Anthropometric measurements and blood pressure measurements were made by a trained professional. The chi-square (X 2) test, odds ratio, normality distribution (verified by the Kolmogorov-Smirnov test), and Levene's test were used to analyze the variables. To evaluate the effect of MS, HF, and the interaction between MS and HF, two-way analysis of variance (ANOVA) was performed based on the homogeneity of the variances, followed by Bonferroni's post hoc comparisons. Spearman correlation analysis was performed to evaluate the relationship between quantitative variables. A multiple linear regression model was used to analyze the effect of covariables. A logistic regression model was built to analyze the variables that contribute significantly to predict the outcome (HF) using the backward method. Results: Our results showed that 57% of men and 49.5% of women presented with MS; 44% of men and 11% of women presented with HF. The presence of MS and hypertriglyceridemia increase the probability of having HF by up to 2.1 and 1.88 times, respectively, while for male sex it is increased by 6.2 times. Patients with HF have higher values of C-reactive protein, ferritin, and transferrin saturation, regardless of the presence of MS. The linear regression analysis model indicated that the variables considered in this study explain less than 30% of the variation in ferritin and that the presence of MS in men is responsible for 22% of the variation in the probability of the occurrence of HF. Conclusion: Our results show that hyperferritinemia is closely associated with the components of MS (positive correlation with glycemia, triglycerides levels, blood pressure, and waist circumference, and negative correlation with HDL-c values) in the studied population.

show abstract

Castelli Index and estimative of LDL-c particle size may still help in the clinical practice?

Cited by 11 publications

References 0 publications

Prevalence and correlates of traditional risk factors for cardiovascular disease in a Nigerian ART-naive HIV population: a cross-sectional study

Prevalence and correlates of traditional risk factors for cardiovascular disease in a Nigerian ART-naive HIV population: a cross-sectional study

HDL-C and non-HDL-C levels are associated with anthropometric and biochemical parameters

<p>Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk</p>

Contact Info

Product

Resources

About