Cassia sieberiana root bark used in traditional medicine in Togo: Anthelmintic property against Haemonchus contortus and tannins composition

Kpabi, Iwaba; Munsch, Thibaut; Agban, Amégninou; Thery-Koné, Isabelle; Dorat, Joëlle; Boudesocque-Delaye, Leslie; Delaye, Pierre‐Olivier; Neveu, Cédric; Lanoue, Arnaud; Enguehard‐Gueiffier, Cécile

doi:10.1016/j.sajb.2022.05.055

Cited by 3 publications

(5 citation statements)

References 32 publications

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“…Hydroethanolic extracts of C. sieberiana contain rhein derivatives, anthraquinone compounds especially employed for the treatment of incurable diseases such as arthritis, diabetic nephropathy, and cancer due to their unique mechanism of action [ 19 ]. The anthelmintic properties of the root bark of C. sieberiana and Piliostigma thonningii are attributed to their extracts rich in condensed tannins, flavonoids, and polyols such as D-pinitol, a natural polyol, which also support their ethnopharmacological use [ 27 , 28 ]. The presence of various metabolites in different extracts of P. thonningii root bark, such as hydroxybenzoic acid derivatives, lignans (α-conidendrin), or dipeptides (anabellamide), prove its pharmacological potential through antioxidant and anti-inflammatory activities by activation of NRF2 [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Exploration of the Antioxidant and Anti-inflammatory Potential of Cassia sieberiana DC and Piliostigma thonningii (Schumach.) Milne-Redh, Traditionally Used in the Treatment of Hepatitis in the Hauts-Bassins Region of Burkina Faso

et al. 2023

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Inflammation is the supreme biological response to illness. In the Hauts-Bassins region, in traditional medicine, all parts of Cassia sieberiana and Piliostigma thonningii are used to treat hepatitis and inflammation. The aim of this study was to evaluate the in vitro antioxidant and anti-inflammatory activities of their aqueous extracts. High performance liquid chromatography with photodiode array (HPLC-DAD) and ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-MS/MS) analyses highlighted the presence of polyphenols and flavonoids. Antioxidant and anti-inflammatory activities were measured by various methods such as DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), TAC (total antioxidant capacity), anti-protease, anti-lipoxygenase, and membrane stabilization. The best antioxidant activity was observed in the bark (DPPH: IC50 = 13.45 ± 0.10µg/mL) and roots (TAC = 29.68 ± 1.48 mgAAE/g DW) of Piliostigma thonningii and in the roots (ABTS: IC50 = 1.83 ± 0.34 µg/mL) of Cassia sieberiana. The best anti-inflammatory activity was observed in the bark (anti-lipoxygenase: IC50 = 13.04 ± 1.99 µg/mL) and leaves (anti-proteases: IC50 = 75.74 ± 1.07 µg/mL, membrane stabilization: IC50 = 48.32 ± 6.39 µg/mL) of Cassia sieberiana. Total polyphenols (ABTS: r = −0.679, TAC: r = 0.960) and condensed tannins (ABTS: r = −0.702, TAC: r = 0.701) were strongly correlated with antioxidant activity. Total flavonoids (anti-proteases: r = −0.729), condensed tannins (anti-proteases: r = 0.698), and vitamin C (anti-proteases: r = −0.953) were strongly correlated with anti-inflammatory activity. Total polyphenols, flavonoids, condensed tannins, and vitamin C could contribute to the antioxidant and anti-inflammatory activities of the two studied plants. These results could validate the traditional use of these plants to treat various inflammatory diseases.

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Section: Introductionmentioning

confidence: 99%

Exploration of the Antioxidant and Anti-inflammatory Potential of Cassia sieberiana DC and Piliostigma thonningii (Schumach.) Milne-Redh, Traditionally Used in the Treatment of Hepatitis in the Hauts-Bassins Region of Burkina Faso

et al. 2023

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“…Other studies have shown that reduction of parasite load can also be achieved by administering plant extracts with high tannin content, resulting in up to 64% reduction in H. contortus egg shedding/gram of faeces in goats [ 39 ], up to 96.5% reduction using bird’s foot trefoil-based extracts [ 17 ], and recently, in 2022, up to 30.3% efficacy against H. contortus was demonstrated, also using tannin-based plant extracts [ 18 ], the latter value being close to that in our experiment. This decrease in the number of eggs/gram of faeces can be attributed to the larvicidal effect exerted by the plant extract based on condensed tannins on larvae 3 of H. contortus [ 6 ] as well as to the negative effect of these tannins on trichostrongylus females, represented by low fecundity after exposure to condensed tannins [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, as an alternative to helminth chemoresistance, over time, the antiparasitic effects of several plants with tannin content ( Lotus corniculatus, Cichorium intybus, Onobrychis , etc.) have been tested [ 15 , 16 , 17 , 18 , 19 ]. The antiparasitic effect of these plants has been tested over the years both by direct administration of the plant as such [ 15 ] or by using plant extracts containing antiparasitic substances [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Research on the Control of Gastrointestinal Strongyles in Sheep by Using Lotus corniculatus or Cichorium intybus in Feed

Cireșan,

Cocan,

Alexa

et al. 2023

Pathogens

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The general practice of sheep farmers in gastrointestinal helminth control is based on the use of commercial drugs, making chemoresistance very common. Considering this, our study focused on the biological control of gastrointestinal parasitism using high-tannin plant hay. Three groups of 30 animals each were formed. The control group was additionally fed meadow hay, while the other two groups received chicory (group 2) and bird’s foot trefoil hay (group 3). The number of gastrointestinal strongyle eggs, shed through faeces (EPG), was surveyed for 28 days for all animals. The amounts of total tannins for meadow, chicory, and Lotus corniculatus hay supplements were 13.92 mg/g, 78.59 mg/g, and 94.43 mg/g, while their condensed tannin contents were 2.58 mg/g, 29.84 mg/g, and 15.94 mg/g, respectively. Compared to experimental day 0, there was an increase in EPG of 80.83% in the control group, a decrease of 24.72% in group 2, and a 20% decrease in group 3, by day 28. The p-value was <0.05 between group 1 and the other groups, showing significant differences between the control and experimental groups. The decrease in EPG rates in the experimental groups compared to the control group demonstrates an antiparasitic effect of Lotus corniculatus and chicory.

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“…Recently, research has extensively reported that the biologic activity of these compounds is higher than monomeric flavonoids, due to the high number of hydroxyl groups that reduce hydrophobicity [46,[52][53][54][55][56].…”

Section: Dimeric Flavonoidsmentioning

confidence: 99%

Antimicrobial Activity of Dimeric Flavonoids

Lopes,

Campos,

Medeiros

et al. 2024

Compounds

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Distributed throughout the environment are various microorganisms such as bacteria, fungi, parasites, and viruses. Although many are part of the human microbiome, many are pathogenic and cause infections ranging from mild to severe. In recent years, the identification of multidrug-resistant microorganisms has become a serious public health problem. The resulting infections call into question the therapeutic capacity of health systems and lead to approximately 70,000 deaths annually worldwide. The progressive resistance to antibiotics and antifungals has been a major challenge for the medical and pharmaceutical community, requiring the search for new compounds with antimicrobial properties. Several studies have demonstrated the potential of natural and synthesized flavonoids, especially the dimers of these molecules. In this review are presented many examples of dimeric flavonoids that have demonstrated antimicrobial activity against viruses, like influenza and Human Immunodeficiency Virus (HIV), protozoal infections, such as Leishmaniasis and Malaria, fungal infections by Candida albicans and Cryptococcus neoformans, and bacterial infections caused, for example, by Staphylococcus aureus and Escherichia coli. In the pursuit to find potential safe agents for therapy in microbial infections, natural dimeric flavonoids are an option not only for the antimicrobial activity, but also for the low toxicity usually associated with these compounds when compared to classic antimicrobials.

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Cassia sieberiana root bark used in traditional medicine in Togo: Anthelmintic property against Haemonchus contortus and tannins composition

Cited by 3 publications

References 32 publications

Exploration of the Antioxidant and Anti-inflammatory Potential of Cassia sieberiana DC and Piliostigma thonningii (Schumach.) Milne-Redh, Traditionally Used in the Treatment of Hepatitis in the Hauts-Bassins Region of Burkina Faso

Exploration of the Antioxidant and Anti-inflammatory Potential of Cassia sieberiana DC and Piliostigma thonningii (Schumach.) Milne-Redh, Traditionally Used in the Treatment of Hepatitis in the Hauts-Bassins Region of Burkina Faso

Research on the Control of Gastrointestinal Strongyles in Sheep by Using Lotus corniculatus or Cichorium intybus in Feed

Antimicrobial Activity of Dimeric Flavonoids

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