Caspofungin-resistant oral and esophageal candidiasis in a patient with AIDS

Jokela, Janet A.; Kaur, Preeti

doi:10.1097/qad.0b013e3280117f5f

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…It was determined that fluconazole-resistant C. albicans isolates collected from esophagitis patients were sensitive to caspofungin (Hernandez et al, 2004). It was observed that the treatment of azole-resistant oral-esophageal candidiasis cases seen in AIDS patients with caspofungin was successful (Jokela and Kaur, 2007). In our study only 1 (0.9%) of 109 C. albicans strains was resistant to caspofungin.…”

Section: ) Most Non-albicansmentioning

confidence: 59%

Investigation of the susceptibility of Candida species isolated from denture wearers to different antifungal antibiotics

Abaci¹,

Haliki-Uztan²

2011

Afr. J. Microbiol. Res.

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The aim of this study was to determine the the prevalence of in vitro resistance amongst Candida species isolated from the oral cavity of denture wearers. The in vitro susceptibility of 156 Candida isolates to amphotericin B, fluconazole, 5-fluorocytosine, caspofungin and terbinafine was determined. The Clinical Laboratory Standards Institute' (CLSI; formally National Committee for Clinical Laboratory Standards) broth microdilution method was used and MIC 50 and MIC 90 determined. Candida albicans, the most frequently isolated strains, are sensitive to amphotericin (61%) and fluconazole (44%), frequently used agents in the treatment of Candida-associated denture stomatitis. A 100% susceptibility to 5-fluorocytosine was observed among the 109 isolates of C. albicans. Among non C. albicans strains only 1 Candida kefyr strain was determined as susceptible dependent upon dose for 5-fluorocytosine. Among Candida glabrata, the second most common isolate, a 100% susceptibility to caspofungin and 5-fluorocytosine were observed. Since the isolates are sensitive to Caspofungin and 5-fluorocytosine, rarely used in the treatment of oral fungal infections, it is suggested that these antifungal agents be used as alternative medicine in the treatment of oral infections especially caused by strains resistant to amphotericin B and fluconazole.

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Section: ) Most Non-albicansmentioning

confidence: 59%

Investigation of the susceptibility of Candida species isolated from denture wearers to different antifungal antibiotics

Abaci¹,

Haliki-Uztan²

2011

Afr. J. Microbiol. Res.

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Supplement: Trends in invasive Candida infections and their treatment: focus on echinocandins

Lewis

2009

Current Medical Research and Opinion

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Candida spp. are currently the fourth most common cause of bloodstream infections in US hospitals, and the third most common cause of bloodstream infections in the intensive care unit. Over the last 2 decades there has been a shift towards a greater involvement of non-Candida albicans spp. as the cause of candidemia. Several of these non-albicans spp. (e.g., C. glabrata and C. krusei ) exhibit resistance to traditional triazole antifungals like fluconazole, and cross-resistance with newer triazoles, focusing attention on the first-line use of antifungals such as the echinocandins, which possess improved activity against fluconazole-resistant strains. Recent treatment guidelines from the Infectious Diseases Society of America (IDSA) recommend an echinocandin as primary therapy for nonneutropenic or neutropenic patients with moderately severe to severe candidiasis and for patients at risk for infection with a triazole-resistant strain. However, further improvement in candidemia-associated mortality will only be attainable with the development and validation of new diagnostic tools that will allow earlier detection, discrimination, and treatment of invasive candidiasis. Clinicians should remain vigilant to wider emergence of Candida spp. with echinocandin resistance.

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Caspofungin-resistant oral and esophageal candidiasis in a patient with AIDS

Cited by 2 publications

References 8 publications

Investigation of the susceptibility of Candida species isolated from denture wearers to different antifungal antibiotics

Investigation of the susceptibility of Candida species isolated from denture wearers to different antifungal antibiotics

Supplement: Trends in invasive Candida infections and their treatment: focus on echinocandins

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