Caspofungin MIC Distribution amongst  Commonly Isolated  Candida  Species in a  Tertiary Care Centre - An Indian Experience

Wanjare, Shashir

doi:10.7860/jcdr/2016/23731.8883

Cited by 8 publications

(10 citation statements)

References 16 publications

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“…The accumulation of point mutations in one of three hot spot regions of Fks1 has been shown to confer echinocandin resistance ( Garcia-Effron et al, 2009a , Garcia-Effron et al, 2010 , Perlin, 2011 , Arendrup and Perlin, 2014 , Perlin, 2015b , Kolaczkowska and Kolaczkowski, 2016 ). In addition, inherent caspofungin or micafungin sensitivity is known to be variable among Candida species independent of the presence of Fks1 point mutations ( Walker et al, 2013a , Walker et al, 2013b , Arendrup and Perlin, 2014 , Perlin et al, 2015 , Wanjare et al, 2016 ). We demonstrate that, PA sensitivity also differed between Candida strains.…”

Section: Discussionmentioning

confidence: 99%

Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin

et al. 2018

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“…Echinocandins are recommended as first-line therapy for non-neutropenic patients associated with C. albicans and C. glabrata in suspected severe IC conditions [100]. Echinocandins were launched in the early 2000s and became the first-line treatment following the emergence of C. glabrata with reduced susceptibility to fluconazole Colombo et al [101].…”

Section: Echinocandins Resistancementioning

confidence: 99%

Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival

Hassan

Chew

Than

2021

JoF

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Candida glabrata is a yeast of increasing medical relevance, particularly in critically ill patients. It is the second most isolated Candida species associated with invasive candidiasis (IC) behind C. albicans. The attributed higher incidence is primarily due to an increase in the acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic patients. The elderly population and the frequent use of indwelling medical devices are also predisposing factors. This work aimed to review various virulence factors that facilitate the survival of pathogenic C. glabrata in IC. The available published research articles related to the pathogenicity of C. glabrata were retrieved and reviewed from four credible databases, mainly Google Scholar, ScienceDirect, PubMed, and Scopus. The articles highlighted many virulence factors associated with pathogenicity in C. glabrata, including adherence to susceptible host surfaces, evading host defences, replicative ageing, and producing hydrolytic enzymes (e.g., phospholipases, proteases, and haemolysins). The factors facilitate infection initiation. Other virulent factors include iron regulation and genetic mutations. Accordingly, biofilm production, tolerance to high-stress environments, resistance to neutrophil killings, and development of resistance to antifungal drugs, notably to fluconazole and other azole derivatives, were reported. The review provided evident pathogenic mechanisms and antifungal resistance associated with C. glabrata in ensuring its sustenance and survival.

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“…Caspofungin as a fungicidal agent that targets the enzyme complex β‐1,3‐ d ‐glucan synthase and is effective against Candida sp. although its MIC values are species or strain‐dependent (Wanjare et al ., 2016). In relation to S .…”

Section: Resultsmentioning

confidence: 99%

Proteomic profiling and glycomic analysis of the yeast cell wall in strains with Aflatoxin B₁ elimination ability

García‐Béjar

Owens

Briones

et al. 2021

Environmental Microbiology

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The use of microorganisms for Aflatoxin B 1 elimination has been studied as a new alternative tool and it is known that cell wall carried out a critical role. For that reason, cell wall and soluble intracellular fraction of eight yeasts with AFB 1 detoxification capability were analysed. The quantitative and qualitative comparative label-free proteomic allowed the identification of diverse common constituent proteins, which revealed that putative cell wall proteins entailed less than 10% of the total proteome. It was possible to characterize different enzymes linked to cell wall polysaccharides biosynthesis as well as other proteins related with the cell wall organization and regulation. Additionally, the concentration of the principal polysaccharides was determined which permitted us to observe that β-glucans concentration was higher than mannans in most of the samples. In order to better understand the biosorption role of the cell wall against the AFB 1 , an antimycotic (Caspofungin) was used to damage the cell wall structure. This assay allowed the observation of an effect on the normal growth of those yeasts with damaged cell walls that were exposed to AFB 1 . This effect was not observed in yeast with intact cell walls, which may reveal a protective role of this structure against mycotoxins.

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Caspofungin MIC Distribution amongst Commonly Isolated Candida Species in a Tertiary Care Centre - An Indian Experience

Abstract: Emergence of resistance in our study warrants need of elaborate studies with clinical correlation data to detect prevalence of resistance to caspofungin. E-test method proved to be an easy and simple technique for testing susceptibility of Candida to caspofungin.

Cited by 8 publications

References 16 publications

Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin

Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin

Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival

Proteomic profiling and glycomic analysis of the yeast cell wall in strains with Aflatoxin B₁ elimination ability

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Caspofungin MIC Distribution amongst Commonly Isolated Candida Species in a Tertiary Care Centre - An Indian Experience

Abstract: Emergence of resistance in our study warrants need of elaborate studies with clinical correlation data to detect prevalence of resistance to caspofungin. E-test method proved to be an easy and simple technique for testing susceptibility of Candida to caspofungin.

Cited by 8 publications

References 16 publications

Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin

Yeast species-specific, differential inhibition of β-1,3-glucan synthesis by poacic acid and caspofungin

Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival

Proteomic profiling and glycomic analysis of the yeast cell wall in strains with Aflatoxin B1 elimination ability

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Product

Resources

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Proteomic profiling and glycomic analysis of the yeast cell wall in strains with Aflatoxin B₁ elimination ability