Caspofungin-induced fatal complete heart block: Another manifestation of Kounis syndrome

Kounis, Nicholas G.

doi:10.1177/0976500x20130201

Cited by 2 publications

(1 citation statement)

References 8 publications

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“… 7 Kounis syndrome has also been implicated in manifesting as fatal complete heart block. 8 Considering parenteral iron’s history of inducing acute hypersensitivity reactions, it is plausible that parenteral iron may induce Kounis syndrome and precipitate complete heart block and cardiac arrest in a patient with underlying conduction abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Arrest During a Ferric Derisomaltose Infusion Followed by Complete Heart Block: A Case Report

Scott,

Jansen,

Bilello

2024

Clinical Practice and Cases in Emergency Medicine

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Introduction: Ferric derisomaltose is the newest available parenteral iron formulation. Studies have demonstrated a good safety proﬁle with improved tolerability compared to alternative parenteral iron formulations. To date there have been no reported acute, life-threatening cardiac events associated with ferric derisomaltose. Case Report: An 86-year-old male who had previously tolerated routine iron infusions received a ﬁrst dose of ferric derisomaltose at an outpatient infusion clinic. Six minutes into the infusion the patient became unresponsive with no palpable pulse. Return of spontaneous circulation was achieved after two minutes of chest compressions. Electrocardiogram showed complete heart block requiring transcutaneous pacing and vasopressor administration. The patient was transferred to the emergency department for stabilization and then admitted to the cardiac intensive care unit. During admission, the patient received a dual-chamber, permanent pacemaker without complication and was ultimately discharged. Conclusion: It may be reasonable to consider parenteral iron as a toxicological etiology for patients presenting with complete heart block temporally associated with parenteral iron administration, particularly in patients with underlying conduction abnormalities.  

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Section: Discussionmentioning

confidence: 99%

Cardiac Arrest During a Ferric Derisomaltose Infusion Followed by Complete Heart Block: A Case Report

Scott,

Jansen,

Bilello

2024

Clinical Practice and Cases in Emergency Medicine

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Vaccines against candidiasis: Status, challenges and emerging opportunity

Sahu

Bose

Singh

et al. 2022

Front. Cell. Infect. Microbiol.

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Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of fungal infections has considerably increased in the last few years primarily due to an increase in the number of immune-suppressed individuals. Alarming bloodstream infections due to Candida sp. are associated with a higher rate of morbidity and mortality, and are emerged as major healthcare concerns worldwide. Currently, chemotherapy is the sole available option for combating fungal diseases. Moreover, the emergence of resistance to these limited available anti-fungal drugs has further accentuated the concern and highlighted the need for early detection of fungal infections, identification of novel antifungal drug targets, and development of effective therapeutics and prophylactics. Thus, there is an increasing interest in developing safe and potent immune-based therapeutics to tackle fungal diseases. In this context, vaccine design and its development have a priority. Nonetheless, despite significant advances in immune and vaccine biology over time, a viable commercialized vaccine remains awaited against fungal infections. In this minireview, we enumerate various concerted efforts made till date towards the development of anti-Candida vaccines, an option with pan-fugal vaccine, vaccines in the clinical trial, challenges, and future opportunities.

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Caspofungin-induced fatal complete heart block: Another manifestation of Kounis syndrome

Cited by 2 publications

References 8 publications

Cardiac Arrest During a Ferric Derisomaltose Infusion Followed by Complete Heart Block: A Case Report

Cardiac Arrest During a Ferric Derisomaltose Infusion Followed by Complete Heart Block: A Case Report

Vaccines against candidiasis: Status, challenges and emerging opportunity

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