Caspases; Modulators of Apoptosis and Cytokine Maturation — Targets for Novel Therapies

Knight, Melissa J.; Hawkins, Christine J.

doi:10.1007/0-387-23695-3_4

Cited by 1 publication

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“…Survival of pathologic cells (for example cells which are precancerous, infected or those that could elicit autoimmune response) may contribute to cancer, inflammation and autoimmune diseases. On the other hand, removal of essential cells through excessive apoptosis contributes to the pathogenesis of some degenerative diseases [6][7][8] components is therefore, a useful therapeutic approach to counteract either unwanted survival or death of particular cells associated with certain human diseases [9][10][11]. Most apoptotic pathways converge on the proteolytic activation of members of a family of cysteine aspartyl-specific proteases, (caspases).…”

Section: Introductionmentioning

confidence: 99%

The Immune System, Involvement in Neurodegenerative Diseases, Ageing and Cancer

Booy¹,

Johar²,

Kadkhoda³

et al. 2005

CMCAIAA

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This short review was designed to draw the readership's attention to the following articles in the volume. Instead of providing a full summary of topics such as ageing of the immune system and the role of the immune system in ageing, the role of the immune system in the development of cancer and neurodegenerative diseases, it signalizes these topics and provides links to articles that follow as well as to other available literature. Our intention was to provide a new perspective and strengthen the associations between inflammation, cancer, neuro-degenerative diseases, ageing and autoimmunity. The relationship between inflammation, oxidative stress, apoptosis, neurodegeneration and cancer is already, to a certain extent mirrored by attempts of the pharmacologic industry to cross-apply our current knowledge from these fields to develop new treatment modalities. For instance, strategies that modulate cellular redox potential are being applied to restrain inflammation (antioxidants), or to kill cancer cells (prooxidants). Activation of apoptosis or attenuation of resistance of transformed cells towards cell death induction is perhaps the most promising direction chosen by many pharmaceutical companies to develop new classes of drugs. Furthermore, rapidly developing areas of immunology and virology, combined with the tremendous progress in the field of cancer biology and pharmacogenomics, may lead to the occurrence of an unique treatment, based on anti-cancer viral vectors and even anti-inflammatory strategies, which combine multiple pharmacologic activities in a single bio-molecule.

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