Caspase inhibition improves viability and efficiency of liposomal transfection
Tatsushi Yoshida,
Kenta Yamasaki,
Kenjiro Tadagaki
Abstract:High transfection efficiency is the most important point for experiments of DNA and RNA introduction into cells. Decrease of cell viability during the transfection procedure is a crucial issue, resulting in transfection failure. However, the mechanism underlying cell growth inhibition has not been fully elucidated. Lipofection is frequently used for transfection experiments, whereases, depending on cell type, it causes a decrease in cell viability. The present study demonstrates here that a potent pan-caspase … Show more
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