Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

Tummers, Bart; Mari, Luigi; Guy, Clifford S.; Heckmann, Bradlee L.; Rodríguez, Diego A.; Rühl, Sebastian; Moretti, Julien; Crawford, Jeremy Chase; Fitzgerald, Patrick; Kanneganti, Thirumala‐Devi; Janke, Laura J.; Pelletier, S. William; Blander, J. Magarian; Green, Douglas R.

doi:10.1016/j.immuni.2020.04.010

Cited by 93 publications

(99 citation statements)

References 57 publications

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“…Furthermore, it might be suggested that reprogramming of pyroptosis through targeting the proteins of the extrinsic cell death pathway to induce different forms of programmed cell death may lead to a less pathogenic phenotype of SARS-CoV-2. This strategy can be achieved due to the tight cross talk between pyroptosis and apoptosis mediated by the members of extrinsic cell death pathways 25,26,69 . In particular, in recent studies it was shown that inflammasome adaptor ASC recruits procaspase-8 through a PYD/DED interaction 32 .…”

Section: Targeting Dd-mediated Network At the Later Stages Of Sars-cmentioning

confidence: 99%

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications

et al. 2020

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The current pandemic of novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) poses a significant global public health threat. While urgent regulatory measures in control of the rapid spread of this virus are essential, scientists around the world have quickly engaged in this battle by studying the molecular mechanisms and searching for effective therapeutic strategies against this deadly disease. At present, the exact mechanisms of programmed cell death upon SARS-CoV-2 infection remain to be elucidated, though there is increasing evidence suggesting that cell death pathways play a key role in SARS-CoV-2 infection. There are several types of programmed cell death, including apoptosis, pyroptosis, and necroptosis. These distinct programs are largely controlled by the proteins of the death domain (DD) superfamily, which play an important role in viral pathogenesis and host antiviral response. Many viruses have acquired the capability to subvert the program of cell death and evade the host immune response, mainly by virally encoded gene products that control cell signaling networks. In this mini-review, we will focus on SARS-CoV-2, and discuss the implication of restraining the DD-mediated signaling network to potentially suppress viral replication and reduce tissue damage.

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Section: Targeting Dd-mediated Network At the Later Stages Of Sars-cmentioning

confidence: 99%

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications

et al. 2020

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“…Bound TNFR1 interacts with TNFR1-dssociated death domain protein (TRADD), through its DD, which enables the formation of "Complex I". The subsequent formations of "Complex II" ("IIa" or "IIb") operate as molecular platforms to regulate the activation and functions of CASP8 (or CASP10, in some cases) [76,77]. CASP8 activation leads to RCD following two different pathways.…”

Section: Extrinsic Apoptosismentioning

confidence: 99%

“…CASP8 activation is the key process of extrinsic apoptosis; its regulation is complex and also involved in inflammation and antiviral response [77]. cFlip is one of the key components that promotes or inhibits CASP8 oligomerization and ensuing activation by autoproteolytic cleavage.…”

Section: Extrinsic Apoptosismentioning

confidence: 99%

Infection of Mammals and Mosquitoes by Alphaviruses: Involvement of Cell Death

Cappuccio

Maisse

2020

Cells

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Alphaviruses, such as the chikungunya virus, are emerging and re-emerging viruses that pose a global public health threat. They are transmitted by blood-feeding arthropods, mainly mosquitoes, to humans and animals. Although alphaviruses cause debilitating diseases in mammalian hosts, it appears that they have no pathological effect on the mosquito vector. Alphavirus/host interactions are increasingly studied at cellular and molecular levels. While it seems clear that apoptosis plays a key role in some human pathologies, the role of cell death in determining the outcome of infections in mosquitoes remains to be fully understood. Here, we review the current knowledge on alphavirus-induced regulated cell death in hosts and vectors and the possible role they play in determining tolerance or resistance of mosquitoes.

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“…The current protocol focuses on the generation of a Casp8 FL122/123GG missense mutation, but it can be adapted to introduce any missense or nonsense mutation. For complete details on the use and execution of this protocol, please refer to Tummers et al. (2020) .…”

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confidence: 99%

“…For complete details on the use and execution of this protocol, please refer to Tummers et al. (2020) .…”

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confidence: 99%

Generation of Casp8 Mice Using CRISPR-Cas9 Technology

2020

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Summary The purpose of this protocol is to describe the generation of missense mutations in mice using CRISPR-Cas9 technology. The current protocol focuses on the generation of a Casp8 FL122/123GG missense mutation, but it can be adapted to introduce any missense or nonsense mutation. For complete details on the use and execution of this protocol, please refer to Tummers et al. (2020) .

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Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

Cited by 93 publications

References 57 publications

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications

Infection of Mammals and Mosquitoes by Alphaviruses: Involvement of Cell Death

Generation of Casp8 Mice Using CRISPR-Cas9 Technology

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