Caspase-1-dependent pyroptosis of peripheral blood mononuclear cells predicts the development of sepsis in severe trauma patients

Wang, Yuchang; Liu, Qinxin; Liu, Tao; Xie, Xia; Gao, Wei; Bai, Xiangjun; Li, Zhanfei

doi:10.1097/md.0000000000009859

Cited by 53 publications

(46 citation statements)

References 28 publications

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“…A published study reveals an association of NLRP3 and Caspase-1 mRNA levels with severity of sepsis caused by cytomegalovirus (CMV) [126]. Another study suggested that caspase-1 is a potential marker for predicting the development of sepsis after severe trauma [127]. These preclinical and clinical studies have revealed that the regulation of neutrophil pyroptosis may benefit in the treatment of sepsis.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil pyroptosis: new perspectives on sepsis

Liu

Sun

2019

Cell. Mol. Life Sci.

147

104

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Pyroptosis is a caspase-1 or caspase-4/5/11-dependent programmed cell death associated with inflammation, which is initiated by inflammasomes or cytosolic LPS in innate immunity. Sepsis is a life-threatening organ dysfunction caused by an imbalance in the body's response to infection. It is a complex interaction between the pathogen and the host's immune system. Neutrophils play the role of a double-edged sword in sepsis, and a number of studies have previously shown that regulation of neutrophils is the most crucial part of sepsis treatment. Pyroptosis is one of the important forms for neutrophils to function, which is increasingly understood as a host active immune response. There is ample evidence that neutrophil pyroptosis may play an important role in sepsis. In recent years, a breakthrough in pyroptosis research has revealed the main mechanism of pyroptosis. However, the potential value of neutrophil pyroptosis in the treatment of sepsis did not draw enough attention. A literature review was performed on the main mechanism of pyroptosis in sepsis and the potential value of neutrophils pyroptosis in sepsis, which may be suitable targets for sepsis treatment in future.

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Section: Discussionmentioning

confidence: 99%

Neutrophil pyroptosis: new perspectives on sepsis

Liu

Sun

2019

Cell. Mol. Life Sci.

147

104

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“…Overactivated pyroptosis; however, may contribute to sepsis, septic shock, or MODS. Wang et al recently showed that an increased percentage of pyroptotic PBMCs is associated with the development of sepsis.…”

Section: Sting Signaling and Cell Deathmentioning

confidence: 99%

The emerging role of stimulator of interferons genes signaling in sepsis: Inflammation, autophagy, and cell death

Knight

Ren

et al. 2018

Acta Physiologica

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Stimulator of interferons genes (STING) is an adaptor protein that plays a critical role in the secretion of type I interferons and pro-inflammatory cytokines in response to cytosolic nucleic acid. Recent research indicates the involvement of the STING pathway in uncontrolled inflammation, sepsis, and shock. STING signaling is significantly up-regulated in human sepsis, and STING agonists are sug-

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“…Although IL‐6 is up‐regulated in response to TLR signaling cascade, its production can be regulated directly or indirectly by CASP‐1 activation. 1 The proinflammatory cytokines IL‐6 and IL‐33 were higher in mice treated with CASP‐1 peptide inhibitor, whereas anti‐inflammatory cytokines IL‐4 and IL‐13 levels were lower 149 . In contrast, inhibition of CASP‐1 was shown to suppress the mRNA level of IL‐6, indicating that CASP‐1 acts to fine‐tune cytokine and chemokines responses to microbial stimuli 150 .…”

Section: Other Proinflammatory Cytokines and Their Roles In Pyroptosismentioning

confidence: 99%

Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk

Hachim

Khalil

Elemam

et al. 2020

Journal of Leukocyte Biology

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Pyroptosis is a newly discovered programmed cell death with inflammasome formation. Pattern recognition receptors that identify repetitive motifs of prospective pathogens such as LPS of gram‐negative bacteria are crucial to pyroptosis. Upon stimulation by pathogen‐associated molecular patterns or damage‐associated molecular patterns, proinflammatory cytokines, mainly IL‐1 family members IL‐1β and IL‐18, are released through pyroptosis specific pore‐forming protein, gasdermin D. Even though IL‐1 family members are mainly involved in innate immunity, they can be factors in adaptive immunity. Given the importance of IL‐1 family members in health and diseases, deciphering the role of pyroptosis in the regulation of innate and adaptive immunity is of great importance, especially with the recent progress in identifying the exact mechanism of such a pathway. In this review, we will focus on how the innate inflammatory mediators can regulate the adaptive immune system and vice versa via pyroptosis.

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Caspase-1-dependent pyroptosis of peripheral blood mononuclear cells predicts the development of sepsis in severe trauma patients

Abstract: Supplemental Digital Content is available in the text

Cited by 53 publications

References 28 publications

Neutrophil pyroptosis: new perspectives on sepsis

Neutrophil pyroptosis: new perspectives on sepsis

The emerging role of stimulator of interferons genes signaling in sepsis: Inflammation, autophagy, and cell death

Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk

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