Caspase-1 activity of stratum corneum and serum interleukin-18 level are increased in patients with Netherton syndrome

Hosomi, Naoko; Fukai, Kazuyoshi; Nakanishi, Tōru; Funaki, Satoko; Ishii, Masamitsu

doi:10.1111/j.1365-2133.2008.08706.x

Cited by 20 publications

(21 citation statements)

References 9 publications

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“…Grzegorczyk et al, have reported a significant increase in caspase-1 levels in the serum from allergic asthmatic patients as compared to a control group (Grzegorczyk et al, 2002). Caspase-1 activity was increased in patients with Netherton syndrome (Hosomi et al, 2008). In this study, we observed that caspase-1 was activated in the AR mice.…”

Section: Discussionsupporting

confidence: 68%

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Oh¹,

Ryu²,

Cha³

et al. 2012

TANG [HUMANITAS MEDICINE]

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Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVAsensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.

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Section: Discussionsupporting

confidence: 68%

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Oh¹,

Ryu²,

Cha³

et al. 2012

TANG [HUMANITAS MEDICINE]

View full text Add to dashboard Cite

show abstract

“…Grzegorczyk et al (2002) have reported a significant increase in caspase-1 level in serum from allergic asthmatic patients compared with a control group. Caspase-1 activity was increased in patients with the Netherton syndrome (Hosomi et al, 2008). In this study, we observed that caspase-1 jpet.aspetjournals.org was activated in the AR mice.…”

Section: Discussionsupporting

confidence: 53%

Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro

Oh¹,

Kim²,

Jeong³

2011

J Pharmacol Exp Ther

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Because imperatorin (IPT), the furanocoumarins exhibits antiinflammatory activity, we reasoned that IPT might modulate the allergic rhinitis (AR). The aim of this study was to analyze the regulation of AR by IPT. Here, we show the effect and mechanism of IPT in an ovalbumin (OVA)-induced AR model. The number of rubs after the OVA challenge in the OVA-sensitized mice was significantly higher than that in the OVA-unsensitized mice. The increased number of rubs was inhibited by the oral administration of IPT. The increased levels of IgE and histamine in the OVA-sensitized mice were reduced by IPT administration. The levels of interferon-␥ were enhanced, whereas the levels of interleukin (IL)-4 were reduced on the spleen tissue of the IPT-administered AR mice. Protein levels of IL-1␤, macrophage inflammatory protein-2, intercellular adhesion molecule-1, and cyclooxygenase-2 were reduced by IPT administration in the nasal mucosa of the OVA-sensitized mice. In the IPT-administered mice, the number of eosinophils and mast cells infiltration increased by OVA-sensitization were also decreased. In addition, IPT inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, the receptor-interacting protein 2 (RIP2), IB kinase (IKK)-␤, nuclear factor-B (NF-B)/ RelA, and caspase-1 activation were increased, but increased RIP2, IKK-␤, NF-B/RelA, and caspase-1 activation were inhibited by the treatment of IPT. In addition, IPT inhibited caspase-1 activity and IL-1␤ production in IgE-stimulated bone marrowderived mast cells. We can conclude that IPT exerts significant effects by regulating of caspase-1 activation in AR animal and in vitro models.

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“…Indeed, tape striping induces IL1b expression and secretion by keratinocytes (Nickoloff and Naidu, 1994). IL1b, which is strongly expressed in the skin of Spink5 À/À mice (Briot et al, 2009), could then be processed and activated by unrestricted KLK7 (Nylander-Lundqvist and Egelrud, 1997) or caspase 1 (Hosomi et al, 2008), and participated in the recruitment of innate immune cells.…”

Section: Discussionmentioning

confidence: 98%

Par2 Inactivation Inhibits Early Production of TSLP, but Not Cutaneous Inflammation, in Netherton Syndrome Adult Mouse Model

Briot

Lacroix

Robin

et al. 2010

Journal of Investigative Dermatology

101

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Netherton syndrome (NS) is a severe genodermatosis characterized by abnormal scaling and constant atopic manifestations. NS is caused by mutations in SPINK5 (Serine Protease INhibitor Kazal-type 5), which encodes LEKTI (LymphoEpithelial Kazal Type-related Inhibitor). Lack of LEKTI causes stratum corneum detachment secondary to epidermal proteases hyperactivity. Whereas a skin barrier defect is generally regarded as a major cause for atopy, we previously identified a cell-autonomous signaling cascade that triggers pro-Th2 cytokine thymic stromal lymphopoietin (TSLP) production in LEKTI-deficient epidermis. This signaling is initiated by unrestricted kallikrein 5 (KLK5) activity, which directly activates proteinase-activated receptor 2 (PAR2)-mediated expression of TSLP and favors a cutaneous proallergic microenvironment independently of the environment and of the adaptive immune system. To further confirm these results in vivo, we generated Spink5/Par2 double knockout (DKO) mice. At embryonic day 19.5, these mice display a dramatic decrease in TSLP expression, although stratum corneum detachment persists, confirming the role of the KLK5-PAR2 cascade in TSLP-mediated early proallergic signaling. However, deletion of Par2 in adult DKO-grafted skin does not rescue the inflammatory phenotype probably resulting from stratum corneum detachment. We conclude that several mechanisms trigger and maintain the inflammatory phenotype in NS. These include skin barrier impairment, mechanical stress secondary to stratum corneum detachment, as well as protease-induced proinflammatory and proallergic pathways, including PAR2-mediated overexpression of TSLP.

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Caspase-1 activity of stratum corneum and serum interleukin-18 level are increased in patients with Netherton syndrome

Cited by 20 publications

References 9 publications

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro

Par2 Inactivation Inhibits Early Production of TSLP, but Not Cutaneous Inflammation, in Netherton Syndrome Adult Mouse Model

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