Caspar specifies primordial germ cell count and identity inDrosophila melanogaster
Subhradip Das,
Sushmitha Hegde,
Neel Wagh
et al.
Abstract:Repurposing of pleiotropic factors during execution of diverse cellular processes has emerged as a regulatory paradigm. Embryonic development in metazoans is controlled by maternal factors deposited in the egg during oogenesis. Here, we explore maternal role(s) of Caspar (Casp), theDrosophilaorthologue of human Fas-associated factor-1 (FAF1) originally implicated in host-defense as a negative regulator of NF-kB signaling. Maternal loss of either Casp or it's protein partner, Transitional endoplasmic reticulum … Show more
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