CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis

An, Hailong; Chung, Kyung Min; Park, HyunHee; Hong, Jihyun; Gim, Ji-Eun; Choi, Hyosun; Lee, Ye Won; Choi, Jieun; Mun, Ji Young; Yu, Seong‐Woon

doi:10.1080/15548627.2019.1695398

Cited by 53 publications

(42 citation statements)

References 56 publications

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“…CASP9 (caspase-9) is an initiator caspase which prompts intrinsic apoptosis. Nonapoptotic roles of CASP9, including macroautophagy/autophagy regulation, have been also suggested recently (An et al, 2020). Caspase-9 activity is increased in a dose-dependent pattern following Cd exposure which induces oxidative stress in addition to apoptosis in testicular tissue, the apoptosis being mediated via a mitochondria-dependent apoptosis pathway which regulates the activity of the enzyme (Wang et al, 2013 trafficking, turnover, interactions with other organelles, the equilibrium of which results in the appropriate mitochondrial shape, function and distribution within the cell.…”

Section: F I G U R Ementioning

confidence: 94%

Caffeine versus antioxidant combination (Antox) and their role in modifying cadmium‐induced testicular injury in adult male albino rats

Labib

Galal

2020

Andrologia

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The unfavourable outcome of cadmium (Cd) on male fertility, sex hormones' production and sperm criteria have been reported in literature (Medina et al., 2017). Testicular tissue is particularly susceptible to cadmium-induced damage. Cd causes degeneration of rats' epididymis, seminal vesicles and spermatozoa (Sajjad et al., 2014). Cd, other heavy metals and oestrogenic-based compounds may explain the recent deterioration in male fertility in industrialised regions in the form of sperm count and testicular function reduction. This may involve the fact that Cd disrupts endocrine control of testicular tissue and induces oxidative damage (Siu et al., 2009). Cd exposure is linked with the generation of free radicals in acute toxicity and reactive oxygen species (ROS) in chronic toxicity. Cdgenerated superoxide anion, hydrogen peroxide and hydroxyl radicals have been reported and are usually associated with redox reactions and ROS-related genetic alterations. It is, therefore, stated that oxidative damage plays an integral part in cadmium toxicity (Liu et al., 2009). In rats subjected to prenatal Cd exposure, plasma testosterone concentrations are drastically lowered and expression of

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Section: F I G U R Ementioning

confidence: 94%

Caffeine versus antioxidant combination (Antox) and their role in modifying cadmium‐induced testicular injury in adult male albino rats

Labib

Galal

2020

Andrologia

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“…Our recent finding that caspase-9 is activated in an APAF-1-independent manner in insulin-deprived adult hippocampal NSCs provides another intriguing illustration of the interaction of autophagy and apoptosis 89 . Caspase-9 promotes ACD but not apoptosis following insulin withdrawal in adult NSCs 89 . Elucidation of the molecular mechanism by which autophagy directs caspase-9 into ACD rather than apoptosis will greatly advance our understanding of the interconnection between apoptosis and ACD.…”

Section: Molecular Intersection Of Acd and Apoptosismentioning

confidence: 96%

Autophagy as a decisive process for cell death

2020

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Autophagy is an intracellular catabolic pathway in which cellular constituents are engulfed by autophagosomes and degraded upon autophagosome fusion with lysosomes. Autophagy serves as a major cytoprotective process by maintaining cellular homeostasis and recycling cytoplasmic contents. However, emerging evidence suggests that autophagy is a primary mechanism of cell death (autophagic cell death, ACD) and implicates ACD in several aspects of mammalian physiology, including tumor suppression and psychological disorders. However, little is known about the physiological roles and molecular mechanisms of ACD. In this review, we document examples of ACD and discuss recent progress in our understanding of its molecular mechanisms.

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“…In our study, we investigated the expression of CASP9 in order to find out whether the in vitro conditions could modulate the apoptotic signaling in GCs. By contrast to Caspase-3, which serves as an effector caspase, Caspase-9 represents the canonical initiator caspase in the intrinsic mitochondrial pathway [29]. In general, mRNA levels of CASP9 did not correlate with BCL2/BAX gene expression at most time points.…”

Section: Discussionmentioning

confidence: 79%

Apoptosis-related genes expression in primary in vitro culture of human ovarian granulosa cells

Kocherova

Stefańska

Bryl

et al. 2020

Medical Journal of Cell Biology

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Ovarian granulosa cells (GCs) play a crucial role in oocyte maturation, creating a favorable microenvironment around the oocyte. Therefore, enhanced apoptosis and GCs loss may negatively affect the intra-follicular milieu and compromise the oocyte quality, reducing pregnancy chances. Based on the RT-qPCR method, the present research revealed the differential expression of apoptosis-related genes (BCL2, BAX, p53, CASP9) during the seven days of primary in vitro culture of GCs isolated from patients undergoing in vitro fertilization (IVF) procedure. Individual gene expression changes may reflect the GCs survival and/or apoptotic status at different time points.Running title: Apoptosis-related genes expression in granulosa cells in vitro

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CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis

Cited by 53 publications

References 56 publications

Caffeine versus antioxidant combination (Antox) and their role in modifying cadmium‐induced testicular injury in adult male albino rats

Caffeine versus antioxidant combination (Antox) and their role in modifying cadmium‐induced testicular injury in adult male albino rats

Autophagy as a decisive process for cell death

Apoptosis-related genes expression in primary in vitro culture of human ovarian granulosa cells

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