CASP1 Gene Polymorphisms and BAT1-NFKBIL-LTA-CASP1 Gene–Gene Interactions Are Associated with Restenosis after Coronary Stenting

Abstract

In the present study, we evaluated the association of the BAT1, NFKBIL, LTA, and CASP1 single nucleotide polymorphisms and the gene–gene interactions with risk of developing restenosis after coronary stenting. The allele and genotype determination of the polymorphisms (BAT1 rs2239527 C/G, NFKBIL1 rs2071592 T/A, LTA rs1800683 G/A, CASP1 rs501192 A/G, and CASP1 rs580253 A/G) were performed by 5’exonuclease TaqMan assays in 219 patients: 66 patients with restenosis and 153 without restenosis. The distribution of rs2239527 C/G, rs2071592 T/A, and rs1800683 G/A polymorphisms was similar in patients with and without restenosis. Nonetheless, under recessive (OR = 2.73, pCRes = 0.031) and additive models (OR = 1.65, pCAdd = 0.039), the AA genotype of the rs501192 A/G polymorphism increased the restenosis risk. Under co-dominant, dominant, recessive, and additive models, the AA genotype of the rs580253 A/G was associated with a high restenosis risk (OR = 5.38, pCCo-Dom = 0.003; OR = 2.12, pCDom = 0.031; OR = 4.32, pCRes = 0.001; and OR = 2.16, 95%CI: 1.33–3.52, pCAdd = 0.001, respectively). In addition, we identified an interaction associated with restenosis susceptibility: BAT1-NFKBIL1-LTA-CASP1 (OR = 9.92, p < 0.001). In summary, our findings demonstrate that the rs501192 A/G and rs580253 A/G polymorphisms, as well as the gene–gene interactions between BAT1-NFKBIL1-LTA-CASP1, are associated with an increased restenosis risk after coronary stenting.

Genetic Variants in PHACTR1 & LPL Mediate Restenosis Risk in Coronary Artery Patients

“…Various allelic variants have been linked to a higher risk of ISR in the literature 21 and, more importantly, population-targeted screening for SNPs is imperative to fill the gap associated in the demographic heterogeneity of these genetic variations and their putative associations. 22–25 Vargas-Alarcón et al demonstrated that the CASP1 gene polymorphisms were associated with restenosis in Mexican mestizo patients. 22 Further, Zholdybayeva et al demonstrated that genetic variants in FGB, CD14 and NOS3 genes were associated with restenosis in Kazakh population.…”

“… 22–25 Vargas-Alarcón et al demonstrated that the CASP1 gene polymorphisms were associated with restenosis in Mexican mestizo patients. 22 Further, Zholdybayeva et al demonstrated that genetic variants in FGB, CD14 and NOS3 genes were associated with restenosis in Kazakh population. 24 …”