Casivirimab/Imdevimab Effect on COVID-19 Outcome and Reinfection in a Real-World SARS-COV-2 Variant Transition Period Setting

Tzitzi, Evanthia; Pyrpasopoulou, Athina; Kalmoukos, Panagiotis; Kefas, Aristeidis; Kyrana, Zacharenia; Doukelis, Panagiotis; Varouktsi, Anna; Imprialos, Kostas; Doumas, Michael

doi:10.1089/mab.2022.0033

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…In 2019, the first vaccine against EBOVD was approved by the European Medicines Agency [26]. Apart from remdesivir [27], two monoclonal antibodies targeting the envelope glycoprotein showed promising results [28]. The Ebola genome has a small size of 19 kb, expressing seven structural proteins and seven non-structural proteins.…”

Section: The Role Of Hypusinated Eif-5a and Pas In Ebola Propagationmentioning

confidence: 99%

The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei

Kaiser

2023

Biomolecules

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The triamine spermidine is a key metabolite of the polyamine pathway. It plays a crucial role in many infectious diseases caused by viral or parasitic infections. Spermidine and its metabolizing enzymes, i.e., spermidine/spermine-N1-acetyltransferase, spermine oxidase, acetyl polyamine oxidase, and deoxyhypusine synthase, fulfill common functions during infection in parasitic protozoa and viruses which are obligate, intracellular parasites. The competition for this important polyamine between the infected host cell and the pathogen determines the severity of infection in disabling human parasites and pathogenic viruses. Here, we review the impact of spermidine and its metabolites in disease development of the most important, pathogenic human viruses such as SARS-CoV-2, HIV, Ebola, and in the human parasites Plasmodium and Trypanosomes. Moreover, state-of-the-art translational approaches to manipulate spermidine metabolism in the host and the pathogen are discussed to accelerate drug development against these threatful, infectious human diseases.

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Section: The Role Of Hypusinated Eif-5a and Pas In Ebola Propagationmentioning

confidence: 99%

The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei

Kaiser

2023

Biomolecules

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“… 3 Because of its high transmissibility and its potential to infect those previously vaccinated, the uncertainty of COVID-19 presents a serious challenge to public health again. 4 , 5…”

Section: Introductionmentioning

confidence: 99%

“…3 Because of its high transmissibility and its potential to infect those previously vaccinated, the uncertainty of COVID-19 presents a serious challenge to public health again. 4,5 Alongside physical health hazards, the COVID-19 caused severe mental trauma among general populations. 6 To date, the psychological implications of the COVID-19 epidemic are rapidly being recognized as a public health hazard, and the most frequently reported are depression and anxiety.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Online Mindfulness-Based Stress Reduction on Anxiety and Depression Status of COVID-19 Patients Treated in Fangcang Hospitals: A Randomized Controlled Trial

Li¹,

Chen²,

Ye³

et al. 2023

PRBM

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Background As the focal point of epidemic prevention and control, the mental health of COVID-19 patients cannot be ignored. Online Mindfulness-Based Stress Reduction (MBSR) allows for the provision of conveniently accessible, effective and low-cost interventions on a large scale. We aim to evaluate the effectiveness of an online MBSR intervention in alleviating anxiety and depression among asymptomatic/mild patients limited by COVID-19-related restrictions. Methods Fifty-eight patients treated in Sanya Fangcang hospital were randomly allocated to either to the experimental group (n = 29) following daily, for 5 days, an online-based mindfulness intervention or to the control group (n = 29). Patients from both groups underwent online questionnaires including assessment of anxiety and depression status at pre- and post-tests using Self-rating Anxiety Scale and Self-Rating Depression Scale. Results After the online-based MBSR program, the anxiety and depression scores of the patients in the MBSR group decreased significantly in comparison to the scores of those in the control group (respectively η 2 = 0.175, η 2 = 0.215, p < 0.001). And the proportion of severe anxiety and depression patients in the MBSR group decreased to 0% which lower than the control group, and the proportion of light anxiety and depression patients was significantly more than that in the control group after the MBSR intervention. Conclusion The online-based MBSR intervention appears to be an effective way of alleviating anxiety and depression symptoms among COVID-19 patients with associated quarantine in Fangcang hospital. Given the seriousness of mental health threat that could be posed by this ongoing pandemic, our study provides a new idea and method for cost-effective and time-efficient interventions in the future of epidemic prevention and control.

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Casivirimab/Imdevimab Effect on COVID-19 Outcome and Reinfection in a Real-World SARS-COV-2 Variant Transition Period Setting

Cited by 2 publications

References 12 publications

The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei

The Role of Spermidine and Its Key Metabolites in Important, Pathogenic Human Viruses and in Parasitic Infections Caused by Plasmodium falciparum and Trypanosoma brucei

Effect of the Online Mindfulness-Based Stress Reduction on Anxiety and Depression Status of COVID-19 Patients Treated in Fangcang Hospitals: A Randomized Controlled Trial

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