We investigate the Casimir effect, due to the confinement of a scalar field in a D-dimensional sphere, with Lorentz symmetry breaking. The Lorentz-violating part of the theory is described by an additional term λðu • ∂ϕÞ 2 in the scalar field Lagrangian, where the parameter λ and the background vector u μ codify the breakdown of Lorentz symmetry. We compute, as a function of D > 2, the Casimir stress by using Green's function techniques for two specific choices of the vector u μ. In the timelike case, u μ ¼ ð1; 0; …; 0Þ, the Casimir stress can be factorized as the product of the Lorentz invariant result times the factor ð1 þ λÞ −1=2. For the radial spacelike case, u μ ¼ ð0; 1; 0; …; 0Þ, we obtain an analytical expression for the Casimir stress which nevertheless does not admit a factorization in terms of the Lorentz invariant result. For the radial spacelike case we find that there exists a critical value λ c ¼ λ c ðDÞ at which the Casimir stress transits from a repulsive behavior to an attractive one for any D > 2. The physically relevant case D ¼ 3 is analyzed in detail where the critical value λ c j D¼3 ¼ 0.0025 was found. As in the Lorentz symmetric case, the force maintains the divergent behavior at positive even integer values of D.