“…The possibility to use a calcium enriched CPP mixture, like the one here employed, forming very stable aggregates, regardless of the extracellular calcium concentration, could overcome these problems, and be of practical relevance when CPP aggregates should be used as functional foods or nutraceuticals (Bosscher, Van Caillie-Bertrand, Van Cawwenbergh, & Deelsdra, 2003;Gaucheron, Le Graet, Boyaval, & Piot, 1997). In this regard, it is worth noting that recent data from our laboratory have demonstrated that the same calcium enriched CPPs were more active in inducing the formation of mineralization nodules in osteoblast-like cells than a calcium free CPP mixture (Donida et al, 2009).…”