Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells
Xuan Luo,
Di Zhang,
Jiaming Zheng
et al.
Abstract:Background
Casein kinase 1α (CK1α), expressed in both ovarian germ and somatic cells, is involved in the initial meiosis and primordial follicle formation of mouse oocytes. Using in vitro and in vivo experiments in this study, we explored the function and mechanism of CK1α in estrogen synthesis in mice ovarian granulosa cells.
Methods
A CK1α knockout (cKO) mouse model, targeted specifically to ovarian granulosa cells (GCs), was employed to establis… Show more
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