Casein (CSN) gene variants and parity affect the milk protein traits in crossbred (Bos taurus x Bos indicus) cows in sub-tropical climate

Mohan, G. Krishna; Kumar, Amarjeet; Khan, Suhail Hakeem; Kumar, Naveen; Kapila, Suman; Lathwal, S. S.; Sodhi, Monika; Niranjan, S. K.

doi:10.1007/s11250-021-02736-w

Cited by 8 publications

(7 citation statements)

References 31 publications

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“…Our data were compared with other published data based on group-based genotypes, considering that the B, C, F, and G variants are the A1 group and the A3, D, E, H1, H2, and I variants are the A2 group ( Table 4 ). The frequency of the A2 allele (0.816) in this study was numerically higher than those reported for Holsteins (0.508–0.744) [ 3 , 7 , 8 , 9 , 11 , 12 , 13 ], crossbreeds (0.568–0.606) [ 14 , 15 , 16 ], Mexican Jerseys (0.738) [ 10 ], and Danish Jerseys (0.700) [ 8 ]. If the herd aims to produce milk only from the A2 variant (A2 milk), a high frequency of the A2 allele is favored for selected breeding.…”

Section: Resultscontrasting

confidence: 74%

Frequency of β-Casein Gene Polymorphisms in Jersey Cows in Western Japan

Nuomin

Nguyen

Aodaohu

et al. 2022

Animals

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This study aimed to investigate β-casein gene polymorphisms in Jersey cows in Japan. Blood samples were collected from 590 cows from eight Jersey farms in Okayama Prefecture, western Japan. Sequence analysis of exon 7 regions in chromosome 6 of the CSN2 gene revealed the genotype and allele frequencies of the β-casein variants. Considering that variant B belongs to the A1 group and variant I to the A2 group, plasma metabolite concentrations were compared among the A1A1, A1A2, and A2A2 group-based genotypes. The most frequent genotype was A2A2 (0.558), followed by A2B (0.190) and A2I (0.103). No variants of A3, F, G, H1, or H2 were found. The frequencies of group-based genotypes were A1A1 (0.032), A1A2 (0.303), and A2A2 (0.665). Although farm-to-farm differences were observed in the plasma concentrations of urea nitrogen, calcium, and phosphorus, no differences were found between the A1A1, A1A2, and A2A2 group-based genotypes; hence, the β-casein genotypes did not affect the metabolism of major nutrients. Owing to the high frequency of the A2 variant, Jersey cows can be considered an attractive breed for marker-assisted selection to create A2A2 herds.

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Section: Resultscontrasting

confidence: 74%

Frequency of β-Casein Gene Polymorphisms in Jersey Cows in Western Japan

Nuomin

Nguyen

Aodaohu

et al. 2022

Animals

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“…This can identify genes regulating the investigated traits, and with the advancement of agricultural technologies, the understanding of genetic bases underlying target traits has increased drastically [35,36]. Many studies with diverse breeds of dairy sheep have indicated casein gene (CSN) as a promising candidate gene for milk compositions traits [37,38]. Moreover, the SCD gene, SOCS2 and SLC2A2 gene were also chosen as significant candidate genes affecting milk fat, milk protein, or milk quality in recent studies [39][40][41].…”

Section: Genes Affecting Sheep Milk Performancementioning

confidence: 99%

“…Its functions include transporting calcium and phosphate to milk to provide enough calcium and phosphorus for bone formation in young lambs and to meet amino acid requirements. Casein includes α S1-casein (CSN1S1), α S2-casein (CSN1S2), β-casein (CSN2), and k-casein (CSN3) [37,52,53]. Sheep casein contains 45% β-casein, represented by two phosphorylated forms, β1-casein and β2-casein, which have similar amino acid compositions as bovine β-caseins and have a significant effect on milk protein [54].…”

Section: Csn2 Gene-benefit For the Lactose Intolerancementioning

confidence: 99%

Review: Research Progress of Dairy Sheep Milk Genes

Jiang

2022

Agriculture

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The dairy sheep industry is an important but lacking part of the small ruminant industry. For a sheep breeding program, in addition to wool and meat use, sheep milk can also be processed into high-end dairy products such as cheese and milk powder and bring high economic interests for businesses home and abroad. With increasing interest in sheep milk, the content of which is becoming increasingly clearer, people have found that the nutritional value of sheep milk is higher than that of goat milk and cow milk, with abundant fat yield, protein percentage, and mineral contents, which provide a good opportunity for the development of the sheep milk industry. This review will introduce some dairy sheep breeds with the highest milk production worldwide and compare sheep milk nutrition contents with other ruminants’ milk. Moreover, genes influencing lactation or mammary gland growth like CSN2, SLC2A2, SCD, and SOCS2, which have been revealed in recent studies to significantly affect milk production and milk composition traits will be discussed. For the SLC2A2 gene, working as an important solute carrier to transport small molecular nutrition from blood to milk and SOCS2 gene mutation as an indicator of mastitis, in addition, other genes have been detected that correlate with milk traits, which will be introduced in the review. Some personal opinions into future sheep milk development will be given in the final part of the text. Although the research of sheep milk genetic factors has achieved some progress in recent years, there is still a long way to go.

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“…(Amigo et al 2000;Selvaggi et al 2014). Several studies investigating milk production in sheep have targeted the casein (CSN) gene as a possible candidate for improvement in milk characteristics (Mohan et al 2021). In recent years studies have also focused on SOCS2, SLC2A2, and SCD genes as possible targets for improving quality, fat, and protein (Brenaut et al 2012;Tong et al 2018;Gu et al 2019).…”

Section: Introductionmentioning

confidence: 99%

The investigation of SNP in SOCS2 gene and its effect on milk yield, fat, protein, and somatic cell count in Awassi ewes

hasan,

Ceyhan

2024

Preprint

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Background Livestock farmers face financial losses every year because milk yield and components are severely affected by udder diseases. These udder infections attract the immune response from the host and lead to the influx of neutrophils into milk to fight infection and thus the number of somatic cell count (SCC) is increased. The milk yield and milk quality (e.g. fat) are negatively affected by the increased SCC. The SCC is used to estimate the somatic cell score (SCS)of the milk, which is used as an indirect measure to detect subclinical mastitis. Therefore, the purpose of this study was to investigate the presence of a significant SNP rs868996547, on the suppresser of cytokine signaling 2 gene (SOCS2) which is related to milk yield and milk quality in Awassi sheep. Methods In this study, milk production data was obtained from 210 healthy Awassi ewes with different parties and ages. The general linear model (GLM) process analysis of variance (ANOVA) was used to determine fixed effects on milk traits. The DNA extraction was done using a blood DNA extraction kit from Qiagen. To validate the presence of SNP a customized SNP detection developed by Thermofisher Scientific was used. The presence of the SNP in the SOCS2 gene was detected with genotypes (C/T, T/T, and C/C) and T being the mutated allele and it had a significant (p < 0.015) effect on the milk yield (p < 0,015;0.091), fat (p < 0,001;0,003), fat/protein ratio (p < 0.001;0,037) and log10SCC value (p < 0,006;0,015) of Awassi ewes. However, the protein, total solid, and lactose percentages in the wild type and the mutated ewes found having no significant difference (P > 0.05). Conclusion Our result showed the increase in SCC or SCS of the milk significantly affected the milk yield and composition Parity and age had significant effects on ewes' milk yield (p < 0.001). In conclusion, we investigated the presence of SOCS2 gene of Awassi ewes in the study flock and its effect on milk yield, fat, and somatic cell count, and the change in milk composition and milk yield because of SCC.

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Casein (CSN) gene variants and parity affect the milk protein traits in crossbred (Bos taurus x Bos indicus) cows in sub-tropical climate

Cited by 8 publications

References 31 publications

Frequency of β-Casein Gene Polymorphisms in Jersey Cows in Western Japan

Frequency of β-Casein Gene Polymorphisms in Jersey Cows in Western Japan

Review: Research Progress of Dairy Sheep Milk Genes

The investigation of SNP in SOCS2 gene and its effect on milk yield, fat, protein, and somatic cell count in Awassi ewes

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