Aloe vera, with its immense potential has a rich history of traditional medicine and cosmetic use, addressing various health issues from digestion to dermatological conditions. Its therapeutic versatility arises from a different pharmacological activities, encompassing anti-inflammatory, antibacterial, wound healing, antioxidant, laxative, immunomodulatory, anti-diabetic, skin protective, and potential anti-cancer effects. These effects are attributed to its bioactive compounds ranging from tannins, saponins, flavonoids, terpenoids, alkaloids to triterpenoids, glycosides, glucomannans, chromones, anthraquinones, and anthrone derivatives primarily located in the latex layer of the outer leaf. However, A. vera's toxicity varies with form, with some products exhibiting low toxicity, while others posing risks at high doses.