Case with Brunsting–Perry‐like localized subepidermal blister formations and immunoglobulin G antibodies against unidentified basement membrane zone antigen

Sato-Shibuya, Mami; Dainichi, Teruki; Egawa, Gyohei; Honda, Tetsuya; Otsuka, Atsushi; Ishii, Norito; Hashimoto, Takashi; Kabashima, Kenji

doi:10.1111/1346-8138.13084

Cited by 4 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two cases of BPP were reported with a positive ELISA for laminin-332 (laminin-5) [4]. Also, there is a report of direct and indirect immunofluorescence IgG positivity in the basement membrane zone, but no known dermal or epidermal autoantigens were detected in the immunoblot analyzes, suggesting a rare variant of BPP with autoantibodies to an indeterminate antigen from the basal membrane zone [6]. Finally, a case was described with a discrepancy between the blistering level (intra-lamina lucida) and the location of antigen (lamina densa and sub-lamina densa areas); it can be concluded that BPP includes cases showing characteristics of EBA as well as BP [7].…”

Section: Discussionmentioning

confidence: 99%

Brunsting-Perry Type Pemphigoid Causing Secondary Cicatricial Alopecia in 2 Patients

Dias

Vilar

Bento

et al. 2018

Skin Appendage Disord

View full text Add to dashboard Cite

Brunsting-Perry type pemphigoid (BPP) is a rare subepidermal blistering disease and a cause of secondary cicatricial alopecia. It was originally described by Brunsting and Perry in 1957 as a rare variant of cicatricial pemphigoid, characterized by bullous lesions limited to the head, neck, scalp, and upper trunk with mild or no mucosal involvement. We report 2 cases of BPP cicatricial alopecia with histopathology of subepidermal blister formation, different clinical presentation, and different salt-split test results. One patient had features of bullous pemphigoid (BP) with important oral mucosal involvement (not yet reported in the literature), and the second patient had typical features of epidermolysis bullosa acquisita (EBA). The secondary cicatricial alopecia may be due to different antigens associated with either BP or EBA. The phenomenon of epitope spreading could explain the association between 2 distinctive bullous diseases in the same patient, justifying the divergent findings of the immunofluorescence. The specific target antigen of BPP is yet to be defined.

show abstract

Section: Discussionmentioning

confidence: 99%

Brunsting-Perry Type Pemphigoid Causing Secondary Cicatricial Alopecia in 2 Patients

Dias

Vilar

Bento

et al. 2018

Skin Appendage Disord

View full text Add to dashboard Cite

show abstract

“…Only four younger patients with BPMMP, aged 20–33 years old, were described so far, including two males [M] and two females [F] [Sugita (2001) F/33, Minato (2011) M/31, Sato-Shibuya (2016) F/20, Person (1976) M/29]. 6 , 22–24…”

Section: Discussionmentioning

confidence: 99%

“…11 , 26 Differential diagnosis is additionally complicated by the fact that in some patients with BPMMP, antibodies to type VII collagen, localized in the lower lamina densa and sub-lamina densa have been described which are typical for EBA. 3 , 6 , 10 , 21 , 23 , 28 Consequently, some authors have suggested that Brunsting-Perry CP may represent a clinical, localized variant of EBA 3 , 28–32 . In the study by Joly et al the patient had the typical clinical features of Brunsting-Perry MMP, however DIF studies on salt-split peribullous skin showed IgG and C3 deposits located exclusively on the floor and not on the roof of the blister in a pattern usually found in patients with EBA.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Localized Blistering Eruption of the Face and Neck – A Case Study and Differential Considerations

Michalska-Jakubus¹,

Wdowiak-Filip²,

Kowaléwski³

et al. 2022

CCID

View full text Add to dashboard Cite

We describe a 36-year-old woman with erythematous lesions and well-tense blisters confined to the face and neck of two months history, without mucosal involvement and no triggering factors. A lesional skin biopsy showed a subepidermal blister. Direct immunofluorescence of peribullous skin identified linear deposits of IgG, IgA, and C3 complement along the basement membrane zone, whereas indirect immunofluorescence was negative. Using fluorescence overlay antigen mapping by laser scanning confocal microscopy, linear immunoglobulins deposits were found to be located above collagen IV and below laminin 332 (formerly named laminin 5), in a pattern typical of mucous membrane pemphigoid (formerly named cicatricial pemphigoid). Consequently, in terms of the clinical picture and confocal study, a rare variant of mucous membrane pemphigoid was established, namely Brunsting-Perry type. Combined therapy with oral prednisone and dapsone healed the lesions, leaving atrophic scars and milia. The paper also provides a review of previous reports on this item as well as a comprehensive differential diagnosis of facial blistering lesions.

show abstract

Efficacy and safety of tetracyclines for pemphigoid: a systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

Case with Brunsting–Perry‐like localized subepidermal blister formations and immunoglobulin G antibodies against unidentified basement membrane zone antigen

Cited by 4 publications

References 10 publications

Brunsting-Perry Type Pemphigoid Causing Secondary Cicatricial Alopecia in 2 Patients

Brunsting-Perry Type Pemphigoid Causing Secondary Cicatricial Alopecia in 2 Patients

Localized Blistering Eruption of the Face and Neck – A Case Study and Differential Considerations

Efficacy and safety of tetracyclines for pemphigoid: a systematic review and meta-analysis

Contact Info

Product

Resources

About