Case study: Use of propranolol to reduce aggressive behavior in a woman who is mentally retarded

Abstract

Although neuroleptic medications are frequently used to treat the aggressive behavior of persons with mental retardation, little empirical support exists for their efficacy. In the case study reported here, the beta‐blocker propranolol was used to treat the aggressive behavior of a 23‐year‐old woman with severe mental retardation. Initiation of treatment was correlated with a dramatic decrease in aggression and a less pronounced improvement in self‐injurious behavior (SIB). An increase in resting heart‐rate was associated with a significant increase in aggression, and progressive increases in propranolol dosage were correlated with reductions in heart rate and in significant behavioral improvement. Consideration of propranolol as a less intrusive, and possibly more effective, pharmacologic treatment for the aggressive behavior of persons with mental retardation is discussed.

Zihinsel Engelliliği Olan Bir Ergende Düşük Doz Propranolol ile Agresyonun Başarılı Tedavisi: Bir Olgu Sunumu

“…The dose employed has varied significantly in several studies, and no clear rules have been determined for use in children. The initial doses reported in aggressive behavior in the literature range between 60 mg and 120 mg, while maximum doses range between 120 mg and 360 mg (11,12,13,14). In our case, significant improvement in aggression was determined with propranolol even at a daily dose of 60 mg, and no marked side-effects were observed.…”