Case study: three cats with SLE and erosive polyarthritis

Hanna, F. Y.

doi:10.12968/coan.2013.18.6.256

Cited by 3 publications

(7 citation statements)

References 16 publications

(20 reference statements)

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“…Of these clinical signs, proteinuria, cutaneous lesions and anemia were the most frequent in previously reported cats with SLE (Table 1). [8][9][10][11][12][13][14][15][16][17][18][19][20] Anemia was not included in criteria for this cat as an immune-mediated destruction was uncertain. Although not all infectious or corticosteroid-responsive diseases have been investigated in this case, few infectious diseases could result in all the abnormalities observed in this cat.…”

Section: Discussionmentioning

confidence: 99%

“…The cat presented in this case report is the youngest ever described among cases of SLE already reported, in which the age of diagnosis ranged from 1 to 11.5 years (median 7 years). [8][9][10][11][12][13][14][15][16][17][18][19] SLE may therefore not be ruled out in a very young cat. Similarly, in humans, approximately 25% of SLE cases appear in the first two decades of life.…”

Section: Discussionmentioning

confidence: 99%

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New findings associated with presumptive systemic lupus erythematosus in a kitten

Huvé

Fontaine

Blais

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

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Case summary An 8-month-old neutered male domestic shorthair kitten was examined for anorexia, lethargy and palatine ulcers. Systemic lupus erythematosus (SLE) was suspected based on a positive antinuclear antibody (ANA) titer and six manifestations of autoimmunity: fever, paronychia, oral ulcers, proteinuria, thrombocytopenia and leukopenia. Mastocytemia was observed on the blood smear. Although the clinical presentation of this case meets the classification criteria for SLE in humans, tick-borne disease and histopathology evaluation of the oral and cutaneous lesions would have been necessary to support a definite diagnosis of SLE. Baseline ANA titration was performed in two laboratories with conflicting results, which may reflect substrate differences used for the titration, but a false-positive result cannot be excluded. The cat received prednisolone and all clinical and laboratory abnormalities resolved after two months of treatment. Subsequent ANA titers remained positive and were not correlated to the patient’s clinical progression. Relevance and novel information This report describes new findings associated with a presumptive diagnosis of SLE in a kitten, highlighting that SLE may not be ruled out even in young cats and may be associated with mastocytemia. ANA titration is part of the initial diagnostic work-up of SLE but is a non-specific test and discrepancies can be observed between laboratories. The titration of more specific antibodies such as those used in humans would be helpful to diagnose SLE. ANA titration may not correlate with clinical activity of SLE; hence, the interest of an ANA titer follow-up to establish disease control warrants further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

New findings associated with presumptive systemic lupus erythematosus in a kitten

Huvé

Fontaine

Blais

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

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“…The dosage of the corticosteroids is designed to be reduced gradually. Corticosteroids require careful monitoring as they can cause serious side effects such as increased susceptibility to infection, diabetes and Cushing's syndrome (Bennett 1987, Marks and Henry 2000, Hanna 2013). …”

Section: Discussionmentioning

confidence: 99%

Section: Investigationsmentioning

confidence: 99%

“…A reading <5 was considered normal and a reading ≥5 was considered positive; this test was validated in cats by Professor S.D. Carter, Veterinary Pathology, University of Liverpool (Hanna 2005, 2013). The ANA test was performed to detect serum ANAs (circulating immunoglobulin autoantibodies) in the cats’ serum using an indirect immunofluorescence technique.…”

Section: Investigationsmentioning

confidence: 99%

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Ischaemic neuromyopathy associated with systemic lupus erythematosus in cats

Hanna

2016

Vet Record Case Reports

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Three cats presented to the hospital with multisystemic signs including oral ulceration and bleeding, spontaneous subcutaneous haemorrhages, fever, lethargy, anorexia and renal disease. The cats, two male and one female, were all older than six years (mean age eight years). All three cats also had a chronic history of lameness in one thoracic limb, which had progressed to non-ambulatory paresis. Marked muscle atrophy was present over the entire limb. Palpation of the axilla revealed a prominent tender cord-like structure, which on postmortem examination was found to be the swollen brachial plexus in each cat. The diagnosis of systemic lupus erythematosus was based on clinical assessment and laboratory data. All had ischaemic neuromyopathy confirmed on histopathological examination. Prednisolone with chlorambucil and pentoxifylline was administered orally. Unfortunately, none of the cats survived more than seven weeks from diagnosis.

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Proteinuria

2023

Urinalysis in the Dog and Cat

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Case study: three cats with SLE and erosive polyarthritis

Cited by 3 publications

References 16 publications

New findings associated with presumptive systemic lupus erythematosus in a kitten

New findings associated with presumptive systemic lupus erythematosus in a kitten

Ischaemic neuromyopathy associated with systemic lupus erythematosus in cats

Proteinuria

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