Case study: Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results

Černá, Milena; Malý, Marek; Rudnai, Péter; Középesy, Szilvia; Náray, Miklós; Halzlová, Katarína; Jajcaj, Michal; Grafnetterová, Anna Pinkr; Krsková, Andrea; Antošová, Danuše; Forysová, Kateřina; Hond, Elly Den; Schoeters, Greet; Joas, Reinhard; Casteleyn, Ludwine; Joas, Anke; Biot, Pierre; Aerts, Dominique; Angerer, Jürgen; Bloemen, Louis; Castaño, Argelia; Esteban, Marta; Koch, Holger M.; Kolossa-Gehring, Marike; Gutleb, Arno C.; Pavloušková, Jana; Vrbík, Karel

doi:10.1016/j.envres.2014.10.025

Cited by 26 publications

(14 citation statements)

References 32 publications

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“…The geometric mean concentrations of MBzP and MEHP were higher in our study than were reported for 117 women from the Czech Republic (4.35 and 3.13 μg/g creatinine, respectively), 125 women from Slovakia (3.81 and 3.22 μg/g creatinine, respectively), and 115 women from Hungary (3.82 and 3.70 μg/g creatinine, respectively) ( Černá et al, 2015 ). In contrast, levels of MEOHP and MEHHP were lower in our study, than reported for Czech (11.68 and 18.45 μg/g creatinine, respectively), Slovakian (11.54 and 18.20 μg/g creatinine, respectively), and Hungarian (10.37 and 15.54 μg/g creatinine, respectively) women ( Černá et al, 2015 ). Overall, the distribution of exposures among our study population was unique, yet we identified similarities with values reported for several nearby, non-clinical European populations.…”

Section: Discussioncontrasting

confidence: 72%

“…However, the geometric mean total urine arsenic value for 4,730 Germans aged 18–69 (3.1 μg/g) was substantially lower than for women in our study ( Becker et al, 2003 ). In our study, we determined urinary metabolites of DBP, BzBP, and DEHP as those phthalates most prevalent in Central and Eastern European populations ( Černá et al, 2015 ). The highest urinary phthalates values in our study population were measured for MBP, MBzP, MEHP and MEHHP, while MEHP had the highest geometric mean.…”

Section: Discussionmentioning

confidence: 99%

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Impact of exposure to tobacco smoke, arsenic, and phthalates on locally advanced cervical cancer treatment—preliminary results

Neamtiu

Bloom

Dumitrascu

et al. 2016

PeerJ

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BackgroundCancer research is a national and international priority, with the efficiency and effectiveness of current anti-tumor therapies being one of the major challenges with which physicians are faced.ObjectiveTo assess the impact of exposure to tobacco smoke, arsenic, and phthalates on cervical cancer treatment.MethodsWe investigated 37 patients with locally advanced cervical carcinoma who underwent chemotherapy and radiotherapy. We determined cotinine and five phthalate metabolites in urine samples collected prior to cancer treatment, by gas chromatography coupled to mass spectrometry, and urinary total arsenic by atomic absorption spectrometry with hydride generation. We used linear regression to evaluate the effects of cotinine, arsenic, and phthalates on the change in tumor size after treatment, adjusted for confounding variables.ResultsWe detected no significant associations between urinary cotinine, arsenic, or phthalate monoesters on change in tumor size after treatment, adjusted for urine creatinine, age, baseline tumor size, and cotinine (for arsenic and phthalates). However, higher %mono-ethylhexyl phthalate (%MEHP), a putative indicator of phthalate diester metabolism, was associated with a larger change in tumor size (β = 0.015, 95% CI [0.003–0.03], P = 0.019).ConclusionWe found no statistically significant association between the urinary levels of arsenic, cotinine, and phthalates metabolites and the response to cervical cancer treatment as measured by the change in tumor size. Still, our results suggested that phthalates metabolism may be associated with response to treatment for locally advanced cervical cancer. However, these observations are preliminary and will require confirmation in a larger, more definitive investigation.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Impact of exposure to tobacco smoke, arsenic, and phthalates on locally advanced cervical cancer treatment—preliminary results

Neamtiu

Bloom

Dumitrascu

et al. 2016

PeerJ

View full text Add to dashboard Cite

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“…Human biomonitoring on a. European Scale) study, our results were rather low compared to other Western European Countries [ 17 ]. Furthermore, data from Eastern European countries [ 18 ] also showed higher phthalate concentrations. On the other hand, our results were comparable to findings in Denmark (sampling period 2011) [ 19 ] and from another Austrian study (sampling period 2010/2012) [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Phthalate Metabolites, Consumer Habits and Health Effects

Wallner

Kundi

Hohenblum

et al. 2016

IJERPH

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Phthalates are multifunctional chemicals used in a wide variety of consumer products. The aim of this study was to investigate whether levels of urinary phthalate metabolites in urine samples of Austrian mothers and their children were associated with consumer habits and health indicators. Within an Austrian biomonitoring survey, urine samples from 50 mother-child pairs of five communities (two-stage random stratified sampling) were analysed. The concentrations of 14 phthalate metabolites were determined, and a questionnaire was administered. Monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (5oxo-MEHP), mono-(5-carboxy-2-ethylpentyl) phthalate (5cx-MEPP), and 3-carboxy-mono-propyl phthalate (3cx-MPP) could be quantified in the majority of samples. Significant correlations were found between the use of hair mousse, hair dye, makeup, chewing gum, polyethylene terephthalate (PET) bottles and the diethyl phthalate (DEP) metabolite MEP. With regard to health effects, significant associations of MEP in urine with headache, repeated coughing, diarrhoea, and hormonal problems were observed. MBzP was associated with repeated coughing and MEHP was associated with itching.

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“…1), ale přesto ani u jednoho vzorku nepřesáhly zdravotně významné hodnoty stanovené taktéž německou Komisí pro biomonitoring pro součet obou metabolitů (750 μg/l pro běžnou dospělou populaci, 300 μg/l pro ženy v reprodukčním věku). Pro dětskou populaci byla stanovena zdravotně významná limitní hodnota 500 μg/l (15,16). …”

Section: Diskuseunclassified

Levels of Metabolites of Phthalates, Polycyclic Aromatic Hydrocarbons and Bisphenol A in Urine of Czech Students (Pilot Study)

Grafnetterová¹,

Vrbík²,

Malý³

et al. 2015

Hygiena

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SOUHRNSledování expozice látkám, široce užívaným v průmyslu, a vyhodnocení jejich koncentrací v těle člověka, je jedním z hlavních cílů biologického monitorování obyvatel.V pilotní studii byla sledována hladina metabolitů ftalátu dietylhexylftalátu (DEHP), vybraných metabolitů polyaromatických uhlovodíků a bisfenolu A v moči ve vztahu k možným expozičním zdrojům sledovaných dotazníkovým šetřením. Do studie bylo zařazeno 95 studentů nekuřáků ve věkovém rozmezí 20 až 29 let (44 mužů a 51 žen) z Prahy a Ostravy. Analyty byly stanovová-ny v moči pomocí metody kapalinové chromatografie s tandemovou hmotnostně-spektrometrickou detekcí typu trojitý kvadrupól (LC-MS/MS). Hodnoty metabolitů DEHP u žádného jedince nepřekročily zdravotně významné limitní hodnoty. Za pomoci dotazníku, který byl součástí studie, nebyly zjištěny žádné skutečnosti, které by významně ovlivňovaly hladiny vybraných látek v moči. Byl zjištěn pouze signifikantní vliv pohlaví u 5-OH-MEHP a sumy 5-OH-MEHP a 5-oxo-MEHP, kdy ostravské ženy mají význam-ně vyšší hladiny metabolitů než muži.Klíčová slova: expozice chemickým látkám, polycyklické aromatické uhlovodíky (PAU), ftaláty, bisfenol A (BPA), biologický monitoring SUMMARYThe main target of human biomonitoring is monitoring of exposure and effects of substances used in industry and determination of their concentrations in the human body. In this pilot study the metabolite levels of phthalates, polycyclic aromatic hydrocarbons and bisphenol A were determined in urine. Their association with possible exposure sources was analyzed. The study comprised 95 adults (44 males and 51 females) aged 20 and 29 years from Prague and Ostrava. The analytes in urine samples were determined by liquid chromatography with triple quadrupole tandem mass spectrometry detection (LC-MS/MS). Metabolite levels did not exceed limit values for these biomarkers for any participant. The questionnaire survey, as part of the study, revealed no factors that might affect levels of the selected substances in urine. However, a significant gender-related difference was detected for the level of 5-OH-MEHP and sums of 5-OH-MEHP and 5-oxo-MEHP, where women from Ostrava had significantly higher metabolite values than men. Úvod Sledování expozice populace chemickým látkám kontaminujícím prostředí poskytuje nezbytné informace pro hodnocení zdravotních rizik. V současné době se pozornost věnuje především ftalátům, polyaromatickým uhlovodíkům a bisfenolu A, které mohou porušovat hormonální rovnováhu a nepříznivě ovlivňovat reprodukci či činnost štítné žlázy (1). Přitom se jedná o látky, se kterými člověk přichází do každodenního kontaktu. K expozici populace těmto látkám v běžném prostředí tak dochází v podstatě kontinuálně.Ftaláty se běžně používají k výrobě různých produktů již téměř 50 let a díky jejich chemickým a fyzikálním vlastnostem nalezly široké uplatnění při výrobě řady produktů (2). Mezi nejznámější patří dietylhexylftalát (DEHP), který se až z 90 % využívá k výrobě PVC, ze kterého se relativně snadno uvolňuje. Vzhledem k jeho

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Case study: Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results

Abstract: Some differences were observed between countries in the concentrations of individual urinary phthalate metabolites in children. However, the questionnaire results give no direct explanation for the differences between the countries except the variation in using personal care products.

Cited by 26 publications

References 32 publications

Impact of exposure to tobacco smoke, arsenic, and phthalates on locally advanced cervical cancer treatment—preliminary results

Impact of exposure to tobacco smoke, arsenic, and phthalates on locally advanced cervical cancer treatment—preliminary results

Phthalate Metabolites, Consumer Habits and Health Effects

Levels of Metabolites of Phthalates, Polycyclic Aromatic Hydrocarbons and Bisphenol A in Urine of Czech Students (Pilot Study)

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