Case study of intracerebral plasmacytoma as an initial presentation of multiple myeloma

Wavre, Aurelia; Baur, Audrey S.; Betz, Michael; Mühlematter, Dominique; Jotterand, Martine; Zaman, Khalil; Ketterer, Nicolas

doi:10.1215/15228517-2007-008

Cited by 28 publications

(27 citation statements)

References 5 publications

(5 reference statements)

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“…When involving the skull base as in our observation, plasma cells neoplasms could be asymptomatic. If it's a voluminous mass it may result in tumefaction, pain, headache, single or multiple cranial nerve palsies, or seizure if intracranial extension [6,7]. In our case the patient had a diplopia caused by the left sixth nerve palsy by compression and temporal headache.…”

Section: Discussionmentioning

confidence: 61%

Multiple myeloma revealed by a sphenoid plasmocytoma: case report and literature review

Kadiri

2016

IJMS

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Plasma cell neoplasms can manifest as a solitary or multiple plasmocytomas and may be associated with or progressing to multiple myeloma (MM). Cranial and intracranial plasmocytomas revealing multiple myeloma are very rare and only few cases are reported in the literature. We report the case of a sphenoid plasmocytoma that revealed a multiple myeloma in a 56 year-old woman with 3 months history of temporal headache and diplopia. Magnetic resonance imaging (MRI) and computed tomography (CT) showed a sphenoid mass. An endoscopic sphenoidal biopsy was performed and the histopathological exams showed a plasmocytoma with a positive staining for CD138. Further biological studies confirmed the diagnosis of multiple myeloma with a monoclonal gamma peak of immunoglobulin (Ig) A. The patient started systemic chemotherapy and received decompressive radiation therapy on the sphenoidal sinus. She remained in remission for 8 months and died from renal dysfunction. Although the sphenoid plasmocytoma is a very rare presentation of multiple myeloma it should be considered for effective patient management and prognosis improvement.

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Section: Discussionmentioning

confidence: 61%

Multiple myeloma revealed by a sphenoid plasmocytoma: case report and literature review

Kadiri

2016

IJMS

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“…Only individual case reports and small series described such symptomatology, including cranial nerve palsy [8], visual loss [6] or motor seizures [13]. The apoplectic symptoms are even more uncommon in MM.…”

Section: Discussionmentioning

confidence: 99%

“…As multiple myeloma involvement of the CNS is rare [13], intracranial haemorrhage of the tumour is an extraordinary event in clinical practice. Only one case report of a 57-year-old male can be found in the literature.…”

Section: Discussionmentioning

confidence: 99%

Pseudo-stroke manifestation of multiple myeloma: a report of two cases with literature review

Czapiewski¹,

Szmuda²,

Dzierżanowski³

et al. 2013

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“…These extramedullary plasma cell neoplasms are most commonly seen in the respiratory tract followed by gastrointestinal tract, central nervous system, bladder, breast, testis and lymph nodes [2,3,4]. Central nervous system plasmacytomas are very rare; as per our literature review less than 20 cases have been reported in the English literature [5][6][7][8][9][10][11]. Here we present our experience with a dural plasmacytoma as the initial sign of disease recurrence in a patient with systemic multiple myeloma.…”

Section: Introductionmentioning

confidence: 87%

Parietal Plasmacytoma: An Ominous Sign of Disease Recurrence

Duma¹,

Patel²,

Nasereddin³

2015

AJMCR

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Plasmacytomas located in the central nervous system are rareentities; with no pathognomonic clinical or radiologic features histology is required for a definite diagnosis. We present a case of a dural plasmacytoma as the manifestation of disease recurrence in a patient with systemic multiple myeloma. 51 year old male with history of IgG kappa myeloma, who underwent complete remission after an autologous bone marrow transplant presented to the clinic 10 months post-remission complaining of a "head mass". On physical examination, he was found to have a large soft mass in the parietal area. On MRI the lesion was described as an extra-axial mass, 5.5 cm x5cm diameter, with diffuse enhancement of the dura. Biopsy of the mass revealed anextramedullary plasmacytoma. At that time, his M spike and immunoglobulins levels were unremarkable. Several months after the presentation of the parietal mass, the patient developed recurrence of disease. He underwent a second autologous bone marrow transplant that markedly improved the size of the plasmacytoma. Patient achieved a complete remission after the second transplant. However, 6 months later the dural plasmacytoma increased in size and once again and his myeloma markers remained within normal levels. Unfortunately, recurrence of the multiple myeloma occurred several months later and despite several cycles of chemotherapy, the patient continued to have progression of disease. He then decided for a more conservative treatment and was sent to home hospice. Central nervous system plasmacytomas can present as solitary lesions or as part of systemic multiple myeloma, these tumors tend to have a direct relationship with the activity of the disease and can present as an early sign of recurrence despite normal multiple myeloma markers on peripheral blood. Keywords: dural plasmacytoma, multiple myeloma, solitary plasmacytoma, multiple myeloma recurrenceCite This Article: Narjust Duma MD, Dhruvesh Patel, and Thayer Nasereddin, "Parietal Plasmacytoma: An Ominous Sign of Disease Recurrence." American Journal of Medical Case Reports, vol. 3, no. 6 (2015): 163-166. doi: 10.12691/ajmcr-3-6-4. BackgroundPlasma cell neoplasms can be broadly categorized into multiple myeloma and plasmacytomas. Multiple myeloma, the more common form of plasma cell neoplasms, is composed of abnormal plasma cells that proliferate in the bone marrow. These abnormal cells disrupt normal hematopoiesis, invade adjacent bone and produce paraproteins. Anemia, hypercalcemia, and renal insufficiency are the consequent symptoms of this systemic disease. In contrast to multiple myeloma, plasmacytomas are composed of a mass of neoplastic plasma cells. These masses can be isolated neoplasms with or without the systemic symptoms of multiple myeloma.Plasmacytomas are further subdivided inthree distinct types of plasmacytomas-solitary plasmacytoma of the bone, extramedullary plasmacytoma and multiple plasmacytomas that are either primary or recurrent [1]. Extramedullary plasmacytomas account for 3% of plasma cell neopl...

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Case study of intracerebral plasmacytoma as an initial presentation of multiple myeloma

Cited by 28 publications

References 5 publications

Multiple myeloma revealed by a sphenoid plasmocytoma: case report and literature review

Multiple myeloma revealed by a sphenoid plasmocytoma: case report and literature review

Pseudo-stroke manifestation of multiple myeloma: a report of two cases with literature review

Parietal Plasmacytoma: An Ominous Sign of Disease Recurrence

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